Postgraduate Theses: Recent submissions
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Understanding alpha-synuclein strain-dependent pathology in Parkinson's disease
Published 2026Parkinson’s disease (PD) is defined by α-synuclein (α-syn) aggregation. Distinct polymorphs—flat "ribbons" and cylindrical "fibrils"—are associated with different disease phenotypes, but how cells process these strains and ...USyd AccessThesis -
Adjustment to child autism diagnosis during parent-mediated intervention
Published 2026When a child is diagnosed with autism, their parent goes through a process of working through the associated thoughts and feelings known as adjustment to the diagnosis. Research has yet to investigate whether there are ...Open AccessThesis -
Complexity of 3–manifolds Geometric and Topological Perspectives
Published 2026Minimal triangulations of 3--dimensional manifolds offer key insights to topological and geometric properties of the underlying manifold. We study minimal triangulations through two lenses -- one geometric, and one ...Open AccessThesis -
Evaluation of Large-Scale Single Cell CRISPR Activation Screen
Published 2026The combination of single cell transcriptomics with large-scale CRISPR screening is a powerful approach that enables high throughput characterization of perturbation effect at cellular resolution. While there have been ...USyd AccessThesis -
Decoding the Germline Genome of Paediatric Cancer: Detecting Novel Variants and Determining Their Role in Relation to Cancer Predisposition
Published 2026Cancer development in children does not typically require accumulated somatic mutations introduced by ageing and environmental mutagens, as seen in adult-onset. Rather, germline variants (present in constitutional DNA) are ...USyd AccessThesis