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EXPRESSION OF CYTOCHROME P450 2J2 AND CYCLOOXYGENASE-2 IN HUMAN BREAST CANCER CELLS AND STRATEGIES TO MINIMISE ANTI-TUMOUR DRUG RESISTANCE

Zhang, Jian (University of Sydney Sydney Medical School Discipline of Pharmacology, 2015-12-15)

Advanced cancers are often drug resistant and highly metastatic. Understanding the factors and mechanisms that drive metastasis and drug resistance could provide new targets for the development of innovative treatments ...

Understanding the relationship between telomeres, telomerase, and DNA G-quadruplexes

Moye, Aaron Lavel (University of Sydney Sydney Medical School Children’s Medical Research Institute, 2017-09-29)

Cancer cells elongate their telomeres - G-rich repetitive sequences found at the end of linear chromosomes, allowing limitless replicative potential in these cells. Approximately 85% of cancers use telomerase to ...

The Design and Synthesis of Stabilised Cis- and Trans-Platinum (IV) Complexes for Targeted Drug Delivery

Chen, Catherine (University of Sydney Faculty of Science School of Chemistry, 2016-12-05)

Platinum(IV) complexes are a promising class of pro-drugs which may bypass the problems associated with their platinum(II) counterparts, such as cisplatin and oxaliplatin. However, any pharmacokinetic advantages conferred ...

Melanoma Patterns of Care Study New South Wales

Madronio, Christine Michelle (University of Sydney Sydney Medical School School of Public Health, 2016-03-01)

The MPOC Study was a population-based study of the clinical management of melanoma patients in NSW. It included data on all melanoma diagnoses notified to the cancer registry during a 12-month period, and questionnaire ...

Investigating the effectiveness of a psycho-educational intervention to reduce fear of cancer recurrence in people at high-risk of developing another primary melanoma

Dieng, Mbathio (University of Sydney Sydney Medical School School of Public Health, 2016-04-28)

Melanoma is the fourth most common cancer in Australia and its incidence continue to increase. The diagnosis and treatment of melanoma can impact upon many aspects of an individual’s life, including psychological and ...

Redox Regulation of Protein Kinase B/Akt Function by an Allosteric Disulphide Bond

Yeo, Reichelle (University of Sydney Faculty of Medicine and Health Sydney Medical School, 2019-02-28)

Most proteins in nature are chemically modified after they are made to control how, when and where they function. One type of chemical modification is the cleavage of disulphide bonds that link pairs of cysteine residues ...

The Role of RUNX Transcription Factors in Prostate Development and Tumorigenesis

Ferguson, Alison Mary (University of Sydney Sydney Medical School, 2016-12-22)

Prostate cancer is the most prevalent malignant neoplasia affecting men over 65 years of age. While prostate carcinoma is considered mostly curable when confined to the prostatic capsule, more aggressive forms have a ...

Investigating the effects of novel iron-binding anti-cancer agents on p21Cip1/Waf1 regulation in cancer

Saleh Moussa, Rayan (University of Sydney Sydney Medical School Discipline of Pathology, 2016-12-31)

The cyclin dependent kinase (CDK) inhibitor, p21, is well known for its role in cell cycle arrest and tumour suppression [1]. However, recent studies suggest that, under certain conditions, p21 can promote proliferation, ...

Characterising the phosphorylation of YB-1

Al Jabry, Tariq Saud Hamad (University of Sydney Sydney Medical School Children's Medical Research Institute, 2015-06-30)

The Y-Box-binding protein-1 (YB-1) is a ubiquitous and multifunctional protein involved in several cellular processes such as transcription, mRNA splicing, and translation. YB-1 has been shown to be of significance to the ...

Telomere dynamics in children undergoing cancer treatment and the relationship between telomere length and treatment outcome

Barbaro, Pasquale (University of Sydney Faculty of Medicine and Health Children's Medical Research Institute, 2019-03-08)

Telomeres are specialised DNA structures that protect the ends of linear chromosomes, and their length is important for cell viability. Telomere length declines with age, and there is a large variability seen within the ...