Synthesis and Application of Functionalised Carbohydrates for Targeted Protein Degradation and Bacterial Glycan Recognition

Shepperson, Caitlin Eileen

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Open Access

Field	Value	Language
dc.contributor.author	Shepperson, Caitlin Eileen
dc.date.accessioned	2026-02-15T20:58:57Z
dc.date.available	2026-02-15T20:58:57Z
dc.date.issued	2026	en
dc.identifier.uri	https://hdl.handle.net/2123/34848
dc.description.abstract	Carbohydrates are structurally diverse biomolecules that have essential roles in metabolism, structural organisation, cell signalling, immune recognition, and hostpathogen interactions. The highly specific interactions of carbohydrates with glycanbinding proteins make them attractive targets for investigating biological function as well as development of novel therapeutics. This thesis explores the application of functionalised glycans in two areas of chemical biology, namely targeted protein degradation in liver disease, and glycan recognition in Gram-negative bacterial infections.	en
dc.language.iso	en	en
dc.subject	Carbohydrate Chemistry	en
dc.subject	Nonulosonic Acid	en
dc.subject	Pseudaminic Acid	en
dc.subject	Legionaminic Acid	en
dc.subject	LYTAC	en
dc.subject	CB1	en
dc.title	Synthesis and Application of Functionalised Carbohydrates for Targeted Protein Degradation and Bacterial Glycan Recognition	en
dc.type	Thesis
dc.type.thesis	Doctor of Philosophy	en
dc.rights.other	The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.	en
usyd.faculty	SeS faculties schools::Faculty of Science::School of Chemistry	en
usyd.degree	Doctor of Philosophy Ph.D.	en
usyd.awardinginst	The University of Sydney	en
usyd.advisor	Payne, Richard