Synthesis and Application of Functionalised Carbohydrates for Targeted Protein Degradation and Bacterial Glycan Recognition
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Type
ThesisThesis type
Doctor of PhilosophyAuthor/s
Shepperson, Caitlin EileenAbstract
Carbohydrates are structurally diverse biomolecules that have essential roles in
metabolism, structural organisation, cell signalling, immune recognition, and hostpathogen
interactions. The highly specific interactions of carbohydrates with glycanbinding
proteins make them attractive targets for investigating biological function as well
as development of novel therapeutics. This thesis explores the application of
functionalised glycans in two areas of chemical biology, namely targeted protein
degradation in liver disease, and glycan recognition in Gram-negative bacterial infections.Carbohydrates are structurally diverse biomolecules that have essential roles in
metabolism, structural organisation, cell signalling, immune recognition, and hostpathogen
interactions. The highly specific interactions of carbohydrates with glycanbinding
proteins make them attractive targets for investigating biological function as well
as development of novel therapeutics. This thesis explores the application of
functionalised glycans in two areas of chemical biology, namely targeted protein
degradation in liver disease, and glycan recognition in Gram-negative bacterial infections.
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Date
2026Rights statement
The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.Faculty/School
Faculty of Science, School of ChemistryAwarding institution
The University of SydneyShare