Aging and the hepatic disposition of nanoparticles and nanomedicines
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Open Access
Type
ThesisThesis type
Doctor of PhilosophyAuthor/s
Lockwood, Glen PhilipAbstract
The liver and its sinusoidal endothelial cells have a major role in the disposition of nanosubstrates.
This is significant for understanding the effects of aging on the liver and susceptibility to some age- related diseases; and for the therapeutic effects of nanomedicines that target the liver. This is a hybrid thesis consisting of publications and non-published studies with the overarching aim of studying the role of the liver and aging of the liver on the behaviour of nanoparticles (NPs) including nanomedicines.The liver and its sinusoidal endothelial cells have a major role in the disposition of nanosubstrates.
This is significant for understanding the effects of aging on the liver and susceptibility to some age- related diseases; and for the therapeutic effects of nanomedicines that target the liver. This is a hybrid thesis consisting of publications and non-published studies with the overarching aim of studying the role of the liver and aging of the liver on the behaviour of nanoparticles (NPs) including nanomedicines.
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Date
2025Rights statement
The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.Faculty/School
Faculty of Medicine and HealthDepartment, Discipline or Centre
Concord Clinical SchoolAwarding institution
The University of SydneyShare