Formulation strategies for bacteriophage delivery: exploring polymer-based systems
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Type
ThesisThesis type
Doctor of PhilosophyAuthor/s
Liu, ChengxiAbstract
The rise of multidrug-resistant (MDR) bacterial infections poses a significant threat to global public health, highlighting the urgent need for alternative therapeutic strategies. Bacteriophage (phage) therapy has emerged as a promising approach due to its specificity in targeting ...
See moreThe rise of multidrug-resistant (MDR) bacterial infections poses a significant threat to global public health, highlighting the urgent need for alternative therapeutic strategies. Bacteriophage (phage) therapy has emerged as a promising approach due to its specificity in targeting and eliminating antibiotic-resistant bacteria. However, the stability and environmental susceptibility of phages limit their effectiveness. As a result, the encapsulation of phages within polymeric systems has been explored to enhance their stability, bioavailability, and provide sustained release at infection sites. This thesis reviews various formulation strategies for phage delivery, including the use of microparticles, hydrogels, and nanofibers, aimed at protecting phages during formulation, improving their storage stability, and sustaining antimicrobial activity. It further investigates bacteriophage hydrogel formulations and dry powder formulations using natural polymers or the synthetic polymer PLGA, respectively.
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See moreThe rise of multidrug-resistant (MDR) bacterial infections poses a significant threat to global public health, highlighting the urgent need for alternative therapeutic strategies. Bacteriophage (phage) therapy has emerged as a promising approach due to its specificity in targeting and eliminating antibiotic-resistant bacteria. However, the stability and environmental susceptibility of phages limit their effectiveness. As a result, the encapsulation of phages within polymeric systems has been explored to enhance their stability, bioavailability, and provide sustained release at infection sites. This thesis reviews various formulation strategies for phage delivery, including the use of microparticles, hydrogels, and nanofibers, aimed at protecting phages during formulation, improving their storage stability, and sustaining antimicrobial activity. It further investigates bacteriophage hydrogel formulations and dry powder formulations using natural polymers or the synthetic polymer PLGA, respectively.
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Date
2025Rights statement
The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.Faculty/School
Faculty of Medicine and Health, The University of Sydney School of PharmacyAwarding institution
The University of SydneyShare