The use of electrical stimulation to modulate cell behaviour in the nervous system
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USyd Access
Type
ThesisThesis type
Doctor of PhilosophyAuthor/s
Huynh, Quy-SusanAbstract
Following injury, the nervous system has poor regenerative capabilities and autologous grafts
and nerve conduits are used to help aid in regeneration especially for large gap peripheral nerve injuries. Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) could ...
See moreFollowing injury, the nervous system has poor regenerative capabilities and autologous grafts and nerve conduits are used to help aid in regeneration especially for large gap peripheral nerve injuries. Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) could improve nerve tissue regeneration but their use is limited by delivery methods and source of BDNF. Therefore, we propose, given the electrically excitable nature of the nervous system, that electrical stimulation (ES) is an avenue to modulate the behaviour and expression of BDNF in cells of the nervous system to aid in nerve tissue regeneration.
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See moreFollowing injury, the nervous system has poor regenerative capabilities and autologous grafts and nerve conduits are used to help aid in regeneration especially for large gap peripheral nerve injuries. Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) could improve nerve tissue regeneration but their use is limited by delivery methods and source of BDNF. Therefore, we propose, given the electrically excitable nature of the nervous system, that electrical stimulation (ES) is an avenue to modulate the behaviour and expression of BDNF in cells of the nervous system to aid in nerve tissue regeneration.
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Date
2024Rights statement
The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.Faculty/School
Faculty of Medicine and HealthDepartment, Discipline or Centre
Department of Medical SciencesAwarding institution
The University of SydneyShare