Engineering protein-based scaffolds for in vitro vascularisation
Access status:
USyd Access
Type
ThesisThesis type
Doctor of PhilosophyAuthor/s
Liu, LinyangAbstract
Despite the rapid development of tissue engineering and regenerative medicine over the past few decades, challenges persist in the vascularisation of engineered tissues in vitro. Inspired by top-down and bottom-up engineering approaches to construct vessel-like networks, this project developed three-dimensional (3D) soft tissue analogues using protein materials including recombinant human tropoelastin (rhTE), silk fibroin (SF) and tyramine-modified gelatin (GT) and explored their vascularisation potential both in vitro and in vivo.Despite the rapid development of tissue engineering and regenerative medicine over the past few decades, challenges persist in the vascularisation of engineered tissues in vitro. Inspired by top-down and bottom-up engineering approaches to construct vessel-like networks, this project developed three-dimensional (3D) soft tissue analogues using protein materials including recombinant human tropoelastin (rhTE), silk fibroin (SF) and tyramine-modified gelatin (GT) and explored their vascularisation potential both in vitro and in vivo.
See less
See less
Date
2024Rights statement
The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.Faculty/School
Faculty of Science, School of Life and Environmental SciencesDepartment, Discipline or Centre
Department of Life and Environmental Sciences Academic OperationsAwarding institution
The University of SydneyShare