Modulation & Comparative Analysis of Small Hydrophilic Molecules Release Mechanisms from Hybrid ‘Liposome-Polymer Macrogel’ Systems

Abstract

This study focuses on the development of a formulation for the controlled release of potent drugs. The objective was to address challenges in drug delivery, such as reaching specific tissues and minimising systemic side effects. The study investigated novel liposomal formulations as efficient delivery vehicles for hydrophilic drugs, aiming to overcome burst-release phenomena commonly observed in the early stages of drug release. Additionally, the study explored hybrid liposome-polymer hydrogel systems to control the release of small hydrophilic drug molecules. Four hybrid models were examined, comparing the release from encapsulated liposomes with non-encapsulated forms. Results showed a significant reduction in burst release and extended-release periods in the encapsulated liposome models. The study also demonstrated the stabilisation of liposomes through peripheral coating with a cationic chitosan polymer, leading to reduced burst release and prolonged release up to 52 consecutive days. Furthermore, the incorporation of maleimide functional groups into liposomes anchored to a polymer backbone resulted in effective attenuation of burst release and prolonged release for up to 62 consecutive days. The study sheds light on the release mechanisms of small hydrophilic drug molecules from these systems and contributes to a better understanding of release signatures. These findings provide a basis for predicting drug release in future studies.