Safety and tolerability of Annona muricata leaf extract in people living with cancer

Abstract

There has been a trend over the last two decades by people living with cancer in their use of natural products to complement or as an alternative to standard care. Annona muricata, also known as graviola, soursop and guanabana. The bark, fruit, seed and leaves had been traditionally used for the management of a wide variety of diseases such as malaria, diabetes and intestinal parasites. Currently, Annona muricata is widely utilised by people living with cancer. Annona muricata and its constituents have been widely studied for their anticancer properties and efficacy, both in-vivo and in-vitro data have been comprehensively reviewed. This project aims to evaluate the safety and tolerability of Annona muricata leaf extract in people living in caner. It involves a systematic review, quality and safety analysis of commercially available Annona muricata products, cancer cell-line studies and an open-label pilot study of Annona muricata in people living with cancer.