Role of an isoflavone metabolite in prevention of skin cancer
Access status:
Open Access
Type
ThesisThesis type
Doctor of PhilosophyAuthor/s
Widyarini, SitarinaAbstract
The aims of the experiments presented in this thesis were to investigate some aspects of chemoprevention by a topically applied isoflavone, equol, its mechanisms and, in particular, its effect on solar-simulated ultraviolet radiation (SSUV)-induced immunosuppression and subsequent development of skin cancer in hairless mouse skin (SkthR-l). A dose-dependent efficacy of equol at micromolar (pM) concentrations has been demonstrated to protect against SSUV-induced skin damage and development of skin cancer.The aims of the experiments presented in this thesis were to investigate some aspects of chemoprevention by a topically applied isoflavone, equol, its mechanisms and, in particular, its effect on solar-simulated ultraviolet radiation (SSUV)-induced immunosuppression and subsequent development of skin cancer in hairless mouse skin (SkthR-l). A dose-dependent efficacy of equol at micromolar (pM) concentrations has been demonstrated to protect against SSUV-induced skin damage and development of skin cancer.
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Date
2002Rights statement
The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.Awarding institution
The University of SydneyShare