Incidence and Outcomes of COVID-19 in People With CKD: A Systematic Review and Meta-analysis
Field | Value | Language |
dc.contributor.author | Chung, Edmund Ym | en_AU |
dc.contributor.author | Palmer, Suetonia C | en_AU |
dc.contributor.author | Natale, Patrizia | en_AU |
dc.contributor.author | Krishnan, Anoushka | en_AU |
dc.contributor.author | Cooper, Tess E | en_AU |
dc.contributor.author | Saglimbene, Valeria M | en_AU |
dc.contributor.author | Ruospo, Marinella | en_AU |
dc.contributor.author | Au, Eric | en_AU |
dc.contributor.author | Jayanti, Sumedh | en_AU |
dc.contributor.author | Liang, Amy | en_AU |
dc.contributor.author | Deng, Danny Jia Jie | en_AU |
dc.contributor.author | Chui, Juanita | en_AU |
dc.contributor.author | Higgins, Gail Y | en_AU |
dc.contributor.author | Tong, Allison | en_AU |
dc.contributor.author | Wong, Germaine | en_AU |
dc.contributor.author | Teixeira-Pinto, Armando | en_AU |
dc.contributor.author | Hodson, Elisabeth M | en_AU |
dc.contributor.author | Craig, Jonathan C | en_AU |
dc.contributor.author | Strippoli, Giovanni Fm | en_AU |
dc.date.accessioned | 2021-09-16T22:00:27Z | |
dc.date.available | 2021-09-16T22:00:27Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | https://hdl.handle.net/2123/26042 | |
dc.description.abstract | RATIONALE & OBJECTIVE: Coronavirus disease 2019 (COVID-19) disproportionately affects people with chronic diseases such as chronic kidney disease (CKD). We assessed the incidence and outcomes of COVID-19 in people with CKD. STUDY DESIGN: Systematic review and meta-analysis by searching MEDLINE, EMBASE, and PubMed through February 2021. SETTING & STUDY POPULATIONS: People with CKD with or without COVID-19. SELECTION CRITERIA FOR STUDIES: Cohort and case-control studies. DATA EXTRACTION: Incidence of COVID-19, death, respiratory failure, dyspnea, recovery, intensive care admission, hospital admission, need for supplemental oxygen, hospital discharge, sepsis, short-term dialysis, acute kidney injury, and fatigue. ANALYTICAL APPROACH: Random-effects meta-analysis and evidence certainty adjudicated using an adapted version of GRADE (Grading of Recommendations Assessment, Development and Evaluation). RESULTS: 348 studies (382,407 participants with COVID-19 and CKD; 1,139,979 total participants with CKD) were included. Based on low-certainty evidence, the incidence of COVID-19 was higher in people with CKD treated with dialysis (105 per 10,000 person-weeks; 95% CI, 91-120; 95% prediction interval [PrI], 25-235; 59 studies; 468,233 participants) than CKD not requiring kidney replacement therapy (16 per 10,000 person-weeks; 95% CI, 4-33; 95% PrI, 0-92; 5 studies; 70,683 participants) and kidney or pancreas-kidney transplant recipients (23 per 10,000 person-weeks; 95% CI, 18-30; 95% PrI, 2-67; 29 studies; 120,281 participants). Based on low-certainty evidence, the incidence of death in people with CKD and COVID-19 was 32 per 1000 person-weeks (95% CI, 30-35; 95% PrI, 4-81; 229 studies; 70,922 participants), which may be higher compared to people with CKD without COVID-19 (incidence rate ratio, 10.26; 95% CI, 6.78-15.53; 95% PrI, 2.62-40.15; 4 studies; 18,347 participants). LIMITATIONS: Analyses were generally based on low-certainty evidence. Few studies reported outcomes in people with CKD without COVID-19 to calculate the excess risk attributable to COVID-19 and potential confounders were not adjusted for in most studies. CONCLUSIONS: The incidence of COVID-19 may be higher in people receiving maintenance dialysis compared to those with CKD not requiring kidney replacement therapy or those who are kidney or pancreas-kidney transplant recipients. People with CKD and COVID-19 may have a higher incidence of death than people with CKD without COVID-19. | en_AU |
dc.language.iso | en | en_AU |
dc.subject | COVID-19 | en_AU |
dc.subject | Coronavirus | en_AU |
dc.title | Incidence and Outcomes of COVID-19 in People With CKD: A Systematic Review and Meta-analysis | en_AU |
dc.type | Article | en_AU |
dc.subject.asrc | 1117 Public Health and Health Services | en_AU |
dc.subject.asrc | 11 Medical and Health Sciences | en_AU |
dc.subject.asrc | 1103 Clinical Sciences | en_AU |
dc.identifier.doi | 10.1053/j.ajkd.2021.07.003 |
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