Browsing Core Research Facilities by subject "COVID-19"
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Assessment of COVID-19 intervention strategies in the Nordic countries using genomic epidemiology
Published 2021Abstract The Nordic countries, defined here as Norway, Sweden, Denmark, Finland and Iceland, are known for their comparable demographics and political systems. Since these countries implemented different COVID-19 intervention ...Preprint -
Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9.
Published 2021The coronaviral nonstructural protein 9 (Nsp9) is essential for viral replication; it is the primary substrate of Nsp12's pseudokinase domain within the viral replication transcription complex, an association that also ...Article -
IFI27 transcription is an early predictor for COVID-19 outcomes; a multi-cohort observational study
Published 2021Robust biomarkers that predict disease outcomes amongst COVID-19 patients are necessary for both patient triage and resource prioritisation. Numerous candidate biomarkers have been proposed for COVID-19. However, at present, ...Preprint -
Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity
Published 2021ABSTRACT Although the respiratory tract is the primary site of SARS-CoV-2 infection and the ensuing immunopathology, respiratory immune responses are understudied and urgently needed to understand mechanisms underlying ...Preprint -
Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
Published 2021SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or convalescent time points, up to 102 days after symptom ...Article -
Intracardiac Echocardiography for Point-of-Care Guided Left Ventricular Assist Device Implantation: Surgical Implications for COVID-19.
Published 2021Data from animal models is now available to initiate assessment of human safety and feasibility of wide-angle three-dimensional intracardiac echocardiography (3D ICE) to guide point-of-care implantation of percutaneous ...Article -
Risk awareness during operation of analytical flow cytometers and implications throughout the COVID-19 pandemic
Published 2021The COVID-19 pandemic has brought biosafety to the forefront of many life sciences. The outbreak has compelled research institutions to re-evaluate biosafety practices and potential at-risk areas within research laboratories ...Article -
Sars-CoV-2 Genome Sequencing Methods Differ In Their Ability To Detect Variants From Low Viral Load Samples.
Published 2021SARS-CoV-2 genomic surveillance has been vital in understanding the spread of COVID-19, the emergence of viral escape mutants and variants of concern. However, low viral loads in clinical specimens affect variant calling ...Article