Does Upper Airway Deformation Affect Drug Deposition?

Abstract

Knowledge that enables the accurate simulation of drug deposition in the human upper airway is necessary to develop robust platforms for efficient drug delivery by inhalation devices. The human upper airway is deformable during inhalation but how it could affect deposition of inhaled drugs is unknown. We aimed to determine whether pharyngeal deformation at the soft palate level will have any significant effects on throat deposition, in vitro lung dose and fine particle fraction. In this study, dry mannitol powders were delivered to the next-generation cascade impactor (NGI) through the United States Pharmacopeia (USP) throat, and a realistic upper airway cast (RUPAC) at flow rates of 20 40, 60 and 80 Lmin-1. Deformation of the upper airway at 25%, 50%, and 75% in the lateral and antero posterior directions were experimentally simulated in the RUPAC. Throat deposition (p = 0.04) is significantly affected when the upper airway deforms laterally but not antero-posteriorly.