SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings
Field | Value | Language |
dc.contributor.author | Williams, Phoebe C.M. | en_AU |
dc.contributor.author | Howard-Jones, Annaleise R. | en_AU |
dc.contributor.author | Hsu, Peter | en_AU |
dc.contributor.author | Palasanthiran, Pamela | en_AU |
dc.contributor.author | Gray, Paul E. | en_AU |
dc.contributor.author | McMullan, Brendan J. | en_AU |
dc.contributor.author | Britton, Philip N. | en_AU |
dc.contributor.author | Bartlett, Adam W. | en_AU |
dc.date.accessioned | 2020-09-14 | |
dc.date.available | 2020-09-14 | |
dc.date.issued | 2020 | en_AU |
dc.identifier.uri | https://hdl.handle.net/2123/23352 | |
dc.description.abstract | As the SARS-CoV-2 pandemic unfolds across the globe, consistent themes are emerging with regard to aspects of SARS-CoV-2 infection and its associated disease entities in children. Overall, children appear to be less frequently infected by, and affected by, SARS-CoV-2 virus and the clinical disease COVID-19. Large epidemiological studies have revealed children represent less than 2% of the total confirmed COVID-19 cases, of whom the majority experience minimal or mild disease that do not require hospitalisation. Children do not appear to be major drivers of SARS-CoV-2 transmission, with minimal secondary virus transmission demonstrated within families, schools and community settings. There are several postulated theories regarding the relatively low SARS-CoV-2 morbidity and mortality seen in children, which largely relate to differences in immune responses compared to adults, as well as differences in angiotensin converting enzyme 2 distribution that potentially limits viral entry and subsequent inflammation, hypoxia and tissue injury. The recent emergence of a multisystem inflammatory syndrome bearing temporal and serological plausibility for an immune-mediated SARS-CoV-2-related disease entity is currently under investigation. This article summarises the current available data regarding SARS-CoV-2 and the paediatric population, including the spectrum of disease in children, the role of children in virus transmission, and host-virus factors that underpin the unique aspects of SARS-CoV-2 pathogenicity in children. | en_AU |
dc.language.iso | en | en_AU |
dc.subject | COVID-19 | en_AU |
dc.subject | Coronavirus | en_AU |
dc.title | SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings | en_AU |
dc.type | Article | en_AU |
dc.identifier.doi | 10.1016/j.pathol.2020.08.001 |
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