Early life parechovirus infection: a timely review but many questions remain

Abstract

Species A parechoviruses (human parechoviruses), and most prominantly Species A parechoviruses type 3, are now recognised as a leading causes of fever, sepsis-like illness, and CNS infection in young infants (aged <3 months). Although mortality is infrequent, and short-term recovery is common, there have been several studies showing longer-term neurological morbidity following parechovirus infection in infancy. The frequency of and risk factors for adverse neurological outcomes remain inadequately defined.