Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins
Field | Value | Language |
dc.contributor.author | Li, Xiaobing | en_AU |
dc.contributor.author | Xiao, Kangpeng | en_AU |
dc.contributor.author | Chen, Xiaoyuan | en_AU |
dc.contributor.author | Liang, Xianghui | en_AU |
dc.contributor.author | Zhang, Xu | en_AU |
dc.contributor.author | Zhang, Zhipeng | en_AU |
dc.contributor.author | Zhai, Junqiong | en_AU |
dc.contributor.author | Wang, Ruichen | en_AU |
dc.contributor.author | Zhou, Niu | en_AU |
dc.contributor.author | Chen, Zu-Jin | en_AU |
dc.contributor.author | Su, Renwei | en_AU |
dc.contributor.author | Zhou, Fuqing | en_AU |
dc.contributor.author | Holmes, Edward C. | en_AU |
dc.contributor.author | Irwin, David M. | en_AU |
dc.contributor.author | Chen, Rui-Ai | en_AU |
dc.contributor.author | He, Qian | en_AU |
dc.contributor.author | Wu, Ya-Jiang | en_AU |
dc.contributor.author | Wang, Chen | en_AU |
dc.contributor.author | Du, Xue-Qing | en_AU |
dc.contributor.author | Peng, Shi-Ming | en_AU |
dc.contributor.author | Xie, Wei-Jun | en_AU |
dc.contributor.author | Shan, Fen | en_AU |
dc.contributor.author | Li, Wan-Ping | en_AU |
dc.contributor.author | Dai, Jun-Wei | en_AU |
dc.contributor.author | Shen, Xuejuan | en_AU |
dc.contributor.author | Feng, Yaoyu | en_AU |
dc.contributor.author | Xiao, Lihua | en_AU |
dc.contributor.author | Chen, Wu | en_AU |
dc.contributor.author | Shen, Yongyi | en_AU |
dc.date.accessioned | 2020-07-27 | |
dc.date.available | 2020-07-27 | |
dc.date.issued | 2020 | en_AU |
dc.identifier.uri | https://hdl.handle.net/2123/22948 | |
dc.description.abstract | SARS-CoV-2 is having severe impact on public health at a global scale. Malayan pangolin SARS-CoV-2-related coronavirus (SARSr-CoV-2) is closely related to SARS-CoV-2. We show that CT scans of virus-positive pangolins reveal bilateral ground-glass opacities in lungs in similar manner to COVID-19 patients. The virus infected multiple organs in pangolins, with the lungs being the major target. Histological expression showed that ACE2 and TMPRSS2 are co-expressed with viral RNA. Transcriptome analysis revealed an inadequate interferon response, with different dysregulated chemokines and cytokines responses in pregnant and non-pregnant adults and fetuses. Viral RNA and protein were detected in three fetuses providing evidence for vertical virus transmission. In sum, our study identifies the biological framework of SARSr-CoV-2 in pangolins, revealing striking similarities to COVID-19 in humans. | en_AU |
dc.language.iso | en | en_AU |
dc.subject | COVID-19 | en_AU |
dc.subject | Coronavirus | en_AU |
dc.title | Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins | en_AU |
dc.type | Preprint | en_AU |
dc.identifier.doi | 10.1101/2020.06.22.164442 | |
dc.relation.other | Chinese Academy of Sciences | en_AU |
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