Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmissio
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Type
ArticleAuthor/s
White, Sarah L.Rawlinson, William
Boan, Peter
Sheppeard, Vicky
Wong, Germaine
Waller, Karen
Opdam, Helen
Kaldor, John
Fink, Michael
Verran, Deborah
Webster, Angela C
Wyburn, Kate
Grayson, Lindsay
Glanville, Allan
Cross, Nick
Irish, Ashley
Coates, Toby
Griffin, Anthony
Snell, Greg
Alexander, Stephen I.
Campbell, Scott
Chadban, Steven
Macdonald, Peter
Manley, Paul
Mehakovic, Eva
Ramachandran, Vidya
Mitchell, Alicia
Ison, Michael
Abstract
In 2016, the Transplantation Society of Australia and New Zealand, with the support of the Australian Government Or- gan and Tissue authority, commissioned a literature review on the topic of infectious disease transmission from deceased donors to recipients of solid organ transplants. ...
See moreIn 2016, the Transplantation Society of Australia and New Zealand, with the support of the Australian Government Or- gan and Tissue authority, commissioned a literature review on the topic of infectious disease transmission from deceased donors to recipients of solid organ transplants. The purpose of this review was to synthesize evidence on transmission risks, diagnostic test characteristics, and recipient management to inform best-practice clinical guidelines. The final review, presented as a special supplement in Transplantation Direct, collates case reports of transmission events and other peer-reviewed literature, and summa- rizes current (as of June 2017) international guidelines on donor screening and recipient management. Of particular interest at the time of writing was how to maximize utilization of donors at increased risk for transmission of human immunodeficiency virus, hep- atitis C virus, and hepatitis B virus, given the recent developments, including the availability of direct-acting antivirals for hepatitis C virus and improvements in donor screening technologies. The review also covers emerging risks associated with recent epidemics (eg, Zika virus) and the risk of transmission of nonendemic pathogens related to donor travel history or country of origin. Lastly, the implications for recipient consent of expanded utilization of donors at increased risk of blood-borne viral disease transmission are considered.
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See moreIn 2016, the Transplantation Society of Australia and New Zealand, with the support of the Australian Government Or- gan and Tissue authority, commissioned a literature review on the topic of infectious disease transmission from deceased donors to recipients of solid organ transplants. The purpose of this review was to synthesize evidence on transmission risks, diagnostic test characteristics, and recipient management to inform best-practice clinical guidelines. The final review, presented as a special supplement in Transplantation Direct, collates case reports of transmission events and other peer-reviewed literature, and summa- rizes current (as of June 2017) international guidelines on donor screening and recipient management. Of particular interest at the time of writing was how to maximize utilization of donors at increased risk for transmission of human immunodeficiency virus, hep- atitis C virus, and hepatitis B virus, given the recent developments, including the availability of direct-acting antivirals for hepatitis C virus and improvements in donor screening technologies. The review also covers emerging risks associated with recent epidemics (eg, Zika virus) and the risk of transmission of nonendemic pathogens related to donor travel history or country of origin. Lastly, the implications for recipient consent of expanded utilization of donors at increased risk of blood-borne viral disease transmission are considered.
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Date
2018-12-20Publisher
Transplant DirectCitation
White SL, Rawlinson W, Boan P, Sheppeard V, Wong G, Waller K, Opdam H, Kaldor J, Fink M, Verran D, Webster AC, Wyburn K, Chapman JR, Grayson L, Glanville A, Cross NB, Irish A, Coates PT, Griffin A, Snell G, Alexander S, Campbell S, Chadban S, MacDonald P, Manley P, Mehakovic E, Ramachandran V, Mitchell A, Ison M. Infectious disease transmission in solid organ transplantation: donor evaluation, recipient risk and outcomes of transmission. Transplantation Direct 2018; 5(1):e416Share