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dc.contributor.authorMoura Campos Carvalho Silva, Ana Paula
dc.date.accessioned2020-05-05
dc.date.available2020-05-05
dc.date.issued2019-01-01
dc.identifier.urihttps://hdl.handle.net/2123/22199
dc.description.abstractMusculoskeletal pain, such as low back pain, neck/shoulder pain, knee pain and hip pain have high prevalence rates. Many factors are believed to impact these complex conditions. However, it is not well-understood how these musculoskeletal pain conditions are affected by factors such as genetics, physical activity or type 2 diabetes. This thesis aimed to investigate how these factors impact on the prevalence, risk of musculoskeletal pain, particularly low back pain (LBP). Five studies were conducted to achieve these aims. Genetics influences LBP outcomes, but such influence is similar among many different outcomes of LBP, with the exception of the intensity of pain associated with the worst episode. Given the importance of genetics on LBP, researchers will benefit from a data resource that allows for adjustment of genetic factors. As a consequence, The AUstralian Twin BACK pain and physical activity study with one-year follow-up was established to provide great opportunities for future investigations on the relationship between types and dosages of physical activity and LBP by collecting LBP and physical activity status on a weekly and monthly basis, respectively. Regarding type 2 diabetes and its association with musculoskeletal pain, the cross-sectional analyses conducted in this thesis revealed positive and significant associations, mainly with neck/shoulder, hip and knee pain, whereas longitudinal analyses showed that type 2 diabetes only increased the risk of neck/shoulder pain. Of interest, when examining the relationship between the use of metformin and musculoskeletal pain, back pain prevalence was lower amongst those who were taking metformin in people with type 2 diabetes. Finally, amongst those with type 2 diabetes, specific phenotypes of participants with obesity, engaged in low levels of physical activity, or those aged over 60 years old, who were taking metformin were less likely to report chronic low back pain than those who were not taking the drug.en_AU
dc.rightsThe author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.en_AU
dc.subjectmusculoskeletal painen_AU
dc.subjectlow back painen_AU
dc.subjectphysical activityen_AU
dc.subjectdiabetesen_AU
dc.subjectgeneticsen_AU
dc.titleThe relationship between genetics, type 2 diabetes, and physical activity with musculoskeletal painen_AU
dc.typeThesisen_AU
dc.type.thesisDoctor of Philosophyen_AU
usyd.facultyFaculty of Health Sciencesen_AU
usyd.degreeDoctor of Philosophy Ph.D.en_AU
usyd.awardinginstThe University of Sydneyen_AU


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