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dc.contributor.authorJohansen, Matt
dc.contributor.authorHortle, Elinor
dc.contributor.authorKasparian, Joshua
dc.contributor.authorRomero, A
dc.contributor.authorNovoa, B
dc.contributor.authorFigueras, A
dc.contributor.authorBritton, Warwick
dc.contributor.authorde Silva, Kumudika
dc.contributor.authorPurdie, Auriol
dc.contributor.authorOehlers, Stefan
dc.date.accessioned2020-02-12T05:25:01Z
dc.date.available2020-02-12T05:25:01Z
dc.date.issued2018-12
dc.identifier.citationJohansen, M. D., Hortle, E., Kasparian, J. A., Romero, A., Novoa, B., Figueras, A., … Oehlers, S. H. (2018). Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility. Fish & Shellfish Immunology, 83, 238–242. https://doi.org/10.1016/j.fsi.2018.09.037en_AU
dc.identifier.urihttps://hdl.handle.net/2123/21836
dc.description.abstractChanges to lipid metabolism are well-characterised consequences of human tuberculosis infection but their functional relevance are not clearly elucidated in these or other host-mycobacterial systems. The zebrafish-Mycobacterium marinum infection model is used extensively to model many aspects of human-M. tuberculosis pathogenesis but has not been widely used to study the role of infection-induced lipid metabolism. We find mammalian mycobacterial infection-induced alterations in host Low Density Lipoprotein metabolism are conserved in the zebrafish model of mycobacterial pathogenesis. Depletion of LDLR, a key lipid metabolism node, decreased M. marinum burden, and corrected infection-induced altered lipid metabolism resulting in decreased LDL and reduced the rate of macrophage transformation into foam cells. Our results demonstrate a conserved role for infection-induced alterations to host lipid metabolism, and specifically the LDL-LDLR axis, across host-mycobacterial species pairings.en_AU
dc.description.sponsorshipThis work was supported by the Australian National Health and Medical Research Council (APP1099912 and APP1053407 to S.H.O.); Meat and Livestock Australia (P.PSH. 0813 to A.C.P. and K. dS); the Marie Bashir Institute for Infectious Diseases and Biosecurity (grant to S.H.O., A.C.P. and K. dS); the Kenyon Family Foundation Inflammation Award (grant to S.H.O.); the University of Sydney (fellowship to S.H.O.); Consellería de Economía, Emprego e Industria (GAIN), Xunta de Galicia (grant IN607B 2016/12 to Institute of Marine Research (IIM-CSIC)).en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.relationNHMRC APP1053407 and APP1099912en_AU
dc.subjectGranuloma; Lipid; Mycobacterium; Pathogenesis; Zebrafishen_AU
dc.titleAnalysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibilityen_AU
dc.typeArticleen_AU
dc.subject.asrcFoR::110707 - Innate Immunityen_AU
dc.subject.asrcFoR::110801 - Medical Bacteriologyen_AU
dc.identifier.doi10.1016/j.fsi.2018.09.037
dc.type.pubtypePre-printen_AU


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