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dc.contributor.authorCrouse, Jacob
dc.contributor.authorChitty, Kate
dc.contributor.authorIorfino, Frank
dc.contributor.authorWhite, Django
dc.contributor.authorNichles, Alissa
dc.contributor.authorZmicerevska, Natalia
dc.contributor.authorGuastella, Adam
dc.contributor.authorMoustafa, Ahmed
dc.contributor.authorHermens, Daniel
dc.contributor.authorScott, Elizabeth
dc.contributor.authorHickie, Ian
dc.date.accessioned2020-01-13T02:52:08Z
dc.date.available2020-01-13T02:52:08Z
dc.date.issued2019-01-17
dc.identifier.citationCrouse JJ, Chitty KM, Iorfino F, White D, Nichles A, et al. (2019) Exploring associations between early substance use and longitudinal socio-occupational functioning in young people engaged in a mental health service. PLOS ONE 14(1): e0210877. https://doi.org/10.1371/journal.pone.0210877en_AU
dc.identifier.urihttps://hdl.handle.net/2123/21652
dc.description.abstractNeuropsychiatric disorders (including substance misuse) are associated with the greatest burden of functional disability in young people, and contributory factors remain poorly understood. Early-onset substance use is one candidate risk factor which may inform functional prognosis and facilitate direction of interventions aiming to curtail impairment. Accordingly, we modelled associations between early-onset use of alcohol, tobacco, cannabis and amphetamine-type stimulants (ATSs) and longitudinal socio-occupational functioning (indexed by the Social and Occupational Functioning Assessment Scale) in an observational cohort presenting to early intervention mental health services. A clinical proforma collated demographic, clinical, and socio-occupational information for up to 60-months from presentation to services in young people aged 17–30. Of the wider cohort (n = 2398), 446 participants were selected with complete alcohol and substance use data. Latent class analysis was used to derive an ‘early-onset’ (n = 243) and ‘later-onset’ class (n = 203) based on age of first use of alcohol, tobacco, cannabis and ATSs. Maximum-likelihood multilevel analyses modelled functioning over time in care and tested associations with substance use latent class, age, gender and diagnosis. Membership in the ‘early-onset’ class (B = -1.64, p = 0.05), male gender (B = -3.27, p<0.001) and psychotic disorder diagnosis (B = -7.62, p<0.001) were associated with poorer functioning at presentation and at least one other time-point. To our knowledge, this is the first study to explore associations of early-onset substance use and longitudinal functioning in a cohort of young people with mental disorders. The identified factors may be useful for directing specific social (e.g. Social Recovery Therapy) or occupational (e.g. Individual Placement and Support) interventions to at-risk individuals, early in illness course.en_AU
dc.description.sponsorshipNational Health & Medical Research Council, Australian Governmenten_AU
dc.language.isoen_USen_AU
dc.publisherPLOS ONEen_AU
dc.relationNHMRC (APP1136259, 1046899)en_AU
dc.rightsCopyright: © 2019 Crouse et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_AU
dc.subjectyouth mental healthen_AU
dc.subjectsubstance useen_AU
dc.subjectdrugsen_AU
dc.subjectalcoholen_AU
dc.subjectpsychiatryen_AU
dc.subjectadolescentsen_AU
dc.subjectyoung adultsen_AU
dc.subjectheadspaceen_AU
dc.subjectdepressionen_AU
dc.subjectbipolar disorderen_AU
dc.subjectschizophreniaen_AU
dc.subjectpsychosisen_AU
dc.subjectanxietyen_AU
dc.subjectsocial functionen_AU
dc.subjectoccupational functionen_AU
dc.subjectvocational functionen_AU
dc.subjectfunctioningen_AU
dc.titleExploring associations between early substance use and longitudinal socio-occupational functioning in young people engaged in a mental health serviceen_AU
dc.typeArticleen_AU
dc.subject.asrcyouth mental healthen_AU
dc.subject.asrcFoR::111714 - Mental Healthen_AU
dc.subject.asrcFoR::110319 - Psychiatry (incl. Psychotherapy)en_AU
dc.identifier.doi10.1371/journal.pone.0210877
dc.type.pubtypePublisher versionen_AU


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