|dc.description.abstract||INTRODUCTION: 4D-MRI, compared to 4D-CT, provides better soft-tissue contrast for
target delineation. However, motion artefacts are often observed due to residual
breathing variations. This study is to present a retrospective 4D-MRI
reconstruction method based on 2D diaphragm profiles to improve the quality of
4D-MR images in the presence of significant breathing variations.
METHODS: The proposed 4D-MRI reconstruction method utilized diaphragm profiles
(2D cine images on a single sagittal plan at the peak diaphragm) in conjunction
with 4D-MR scans (2D-cine images on multiple pre-determined coronal planes along
the anterior-posterior direction over a volume of interest). The diaphragm
profile images were exploited to sort the 4D-MR scans by matching respiratory
amplitude of diaphragm on the 4D-MR scans to the diaphragm profiles. To evaluate
reconstructed 4D-MR images (ten 3D-MR images), sagittal images on ten 3D-MR
images under free breathing (FB) and respiratory guidance (GB) were compared with
diaphragm profile images (reference) from 13 healthy volunteers.
RESULTS: Forty-four 4D-MR scan datasets were successfully reconstructed without
distinct respiratory-related motion artefacts even with the presence of breathing
variation. The differences in diaphragm profiles between the reference and
corresponding reconstructed images in the mean of root mean square were similar
between FB (3.5 mm) and GB (3.0 mm), confirming that the 4D-MRI reconstruction
method was effective even with significant breathing variation.
CONCLUSIONS: The diaphragm profiles were utilized to reconstruct 4D-MR images
with spatial reliability and a fixed scan time under FB and GB. Our method can
provide reliable 4D information of thoracic and abdominal regions for MRI-guided
|dc.rights||"This is the peer reviewed version of the following article: Lee, D., Kim, S., Palta, J., Lewis, B., Keall, P. and Kim, T. (2019), A retrospective 4D‐MRI based on 2D diaphragm profiles for lung cancer patients. J Med Imaging Radiat Oncol, 63: 360-369., which has been published in final form at https://doi.org/10.1111/1754-9485.12877 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."||en_AU