Fronto-parietal contributions to episodic retrieval – evidence from neurodegenerative disorders
Field | Value | Language |
dc.contributor.author | Ramananan, Siddharth | |
dc.contributor.author | Strikwerda-Brown, Cherie | |
dc.contributor.author | Mothakunnelel, Annu | |
dc.contributor.author | Hodges, John R. | |
dc.contributor.author | Piguet, Olivier | |
dc.contributor.author | Irish, Muireann | |
dc.date.accessioned | 2019-09-20 | |
dc.date.available | 2019-09-20 | |
dc.date.issued | 2019-06-01 | |
dc.identifier.citation | Ramanan, S., Strikwerda-Brown, C., Mothakunnel, A., Hodges, J. R., Piguet, O., & Irish, M. (2019). Fronto-parietal contributions to episodic retrieval—evidence from neurodegenerative disorders. Learning & Memory, 26, 262–271. https://doi.org/10.1101/lm.048454.118 | en_AU |
dc.identifier.uri | http://hdl.handle.net/2123/21136 | |
dc.description.abstract | Converging evidence suggests a critical role for the parietal cortices in episodic memory retrieval. Here, we examined episodic memory performance in Corticobasal Syndrome (CBS), a rare neurodegenerative disorder presenting with early parietal atrophy in the context of variable medial temporal lobe damage. Forty-four CBS patients were contrasted with 29 typical Alzheimer’s disease (AD), 29 healthy Controls, and 20 progressive supranuclear palsy patients presenting with brainstem atrophy as a disease control group. Participants completed standardised assessments of verbal episodic memory (learning, delayed recall, and recognition), and underwent structural and diffusion-weighted MRI. Selective delayed recall deficits were evident in the CBS group relative to Controls, at an intermediate level to the stark amnesia displayed by AD, and Control-level performance noted in progressive supranuclear palsy. Considerable variability within the CBS group on delayed recall performance led to the identification of memory-spared (N = 19) and memory-impaired (N = 25) subgroups. Whereas CBS-Spared showed no significant memory deficits, the CBS-Impaired subgroup were indistinguishable from typical AD across all episodic memory measures. Whole-brain voxel-based morphometry analyses implicated fronto-parietal and medial temporal regions in delayed recall performance in both the CBS-Impaired and AD groups. Furthermore, diffusion tensor imaging analyses revealed correlations between delayed recall performance and altered structural connectivity between fronto-parietal and fronto-temporal regions in the CBS-Impaired group. Our findings underscore the importance of a distributed brain network including frontal, medial temporal and parietal brain regions in supporting the capacity for successful episodic memory retrieval. | en_AU |
dc.language.iso | en_AU | en_AU |
dc.publisher | CSH Press | en_AU |
dc.relation | NHMRC APP1037746; ARC CE110001021; NHMRC APP1132764; NHMRC APP1103258; ARC FT160100096; ARC DP180101548 | en_AU |
dc.subject | Alzheimer’s disease | en_AU |
dc.subject | episodic memory | en_AU |
dc.subject | hippocampus | en_AU |
dc.subject | angular gyrus | en_AU |
dc.subject | prefrontal cortex | en_AU |
dc.title | Fronto-parietal contributions to episodic retrieval – evidence from neurodegenerative disorders | en_AU |
dc.type | Article | en_AU |
dc.subject.asrc | 170101 | en_AU |
dc.identifier.doi | 10.1101/lm.048454.118 | |
dc.type.pubtype | Post-print | en_AU |
dc.description.embargo | 2019-12-30 |
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