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dc.contributor.authorRamananan, Siddharth
dc.contributor.authorStrikwerda-Brown, Cherie
dc.contributor.authorMothakunnelel, Annu
dc.contributor.authorHodges, John R.
dc.contributor.authorPiguet, Olivier
dc.contributor.authorIrish, Muireann
dc.date.accessioned2019-09-20
dc.date.available2019-09-20
dc.date.issued2019-06-01
dc.identifier.citationRamanan, S., Strikwerda-Brown, C., Mothakunnel, A., Hodges, J. R., Piguet, O., & Irish, M. (2019). Fronto-parietal contributions to episodic retrieval—evidence from neurodegenerative disorders. Learning & Memory, 26, 262–271. https://doi.org/10.1101/lm.048454.118en_AU
dc.identifier.urihttp://hdl.handle.net/2123/21136
dc.description.abstractConverging evidence suggests a critical role for the parietal cortices in episodic memory retrieval. Here, we examined episodic memory performance in Corticobasal Syndrome (CBS), a rare neurodegenerative disorder presenting with early parietal atrophy in the context of variable medial temporal lobe damage. Forty-four CBS patients were contrasted with 29 typical Alzheimer’s disease (AD), 29 healthy Controls, and 20 progressive supranuclear palsy patients presenting with brainstem atrophy as a disease control group. Participants completed standardised assessments of verbal episodic memory (learning, delayed recall, and recognition), and underwent structural and diffusion-weighted MRI. Selective delayed recall deficits were evident in the CBS group relative to Controls, at an intermediate level to the stark amnesia displayed by AD, and Control-level performance noted in progressive supranuclear palsy. Considerable variability within the CBS group on delayed recall performance led to the identification of memory-spared (N = 19) and memory-impaired (N = 25) subgroups. Whereas CBS-Spared showed no significant memory deficits, the CBS-Impaired subgroup were indistinguishable from typical AD across all episodic memory measures. Whole-brain voxel-based morphometry analyses implicated fronto-parietal and medial temporal regions in delayed recall performance in both the CBS-Impaired and AD groups. Furthermore, diffusion tensor imaging analyses revealed correlations between delayed recall performance and altered structural connectivity between fronto-parietal and fronto-temporal regions in the CBS-Impaired group. Our findings underscore the importance of a distributed brain network including frontal, medial temporal and parietal brain regions in supporting the capacity for successful episodic memory retrieval.en_AU
dc.language.isoen_AUen_AU
dc.publisherCSH Pressen_AU
dc.relationNHMRC APP1037746; ARC CE110001021; NHMRC APP1132764; NHMRC APP1103258; ARC FT160100096; ARC DP180101548en_AU
dc.subjectAlzheimer’s diseaseen_AU
dc.subjectepisodic memoryen_AU
dc.subjecthippocampusen_AU
dc.subjectangular gyrusen_AU
dc.subjectprefrontal cortexen_AU
dc.titleFronto-parietal contributions to episodic retrieval – evidence from neurodegenerative disordersen_AU
dc.typeArticleen_AU
dc.subject.asrc170101en_AU
dc.identifier.doi10.1101/lm.048454.118
dc.type.pubtypePost-printen_AU
dc.description.embargo2019-12-30


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