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dc.contributor.authorChen, Yu
dc.contributor.authorKumfor, Fiona
dc.contributor.authorLandin-Romero, Ramon
dc.contributor.authorIrish, Muireann
dc.contributor.authorHodges, John R.
dc.contributor.authorPiguet, Olivier
dc.date.accessioned2019-09-06
dc.date.available2019-09-06
dc.date.issued2018-06-07
dc.identifier.citationChen, Y., Kumfor, F., Landin-Romero, R., Irish, M., Hodges, J. R., & Piguet, O. (2018). Cerebellar atrophy and its contribution to cognition in frontotemporal dementias. Annals of Neurology, 84(1), 98–109. https://doi.org/10.1002/ana.25271en_AU
dc.identifier.urihttp://hdl.handle.net/2123/21042
dc.description.abstractObjective: Increasing evidence suggests that cerebellar damage impacts on cognitive functions. Frontotemporal dementias (FTDs) are neurodegenerative brain conditions, primarily affecting the frontal and/or temporal lobe. Three main phenotypes are recognized, each with a distinct clinical and cognitive profile: behavioral-variant FTD (bvFTD), semantic dementia (SD), and progressive nonfluent aphasia (PNFA). The severity of cerebellar changes and their rela- tion to cognition in FTD, however, remain unclear. This study aimed to establish cerebellar gray matter changes on magnetic resonance imaging (MRI) and their relation to profiles of cognitive deficits in FTD subtypes. Methods: Ninety-six FTD patients (45 bvFTD, 28 SD, and 23 PNFA), meeting current clinical diagnostic criteria, and 35 age-, sex-, and education-matched controls underwent brain MRI and cognitive assessment. Cerebral and cerebellar gray matter integrity were investigated using voxel-based morphometry. Results: Compared with controls, widespread bilateral cerebellar changes were observed in all FTD subtypes, with the greatest atrophy present in bvFTD. Significant associations were found between cerebellar integrity and cognitive per- formance in attention and working memory in bvFTD, visuospatial function in SD, and language-motor function in PNFA. Bilateral atrophy of crus and lobule VI were most commonly associated with cognitive deficits, irrespective of FTD phenotype. Interpretation: This study is the first to identify distinct patterns of cerebellar atrophy across FTD syndromes, which in turn relate to discrete cognitive dysfunctions, after accounting for the effect of cerebral atrophy. These findings extend our understanding of the cerebellum and point to its involvement across an array of processes beyond the domain of motor function.en_AU
dc.language.isoenen_AU
dc.publisherWileyen_AU
dc.relationNHMRC APP1037746; ARC CE110001021; NHMRC-ARC APP1097026; ARC FT160100096; NHMRC APP1103258en_AU
dc.subjectcerebellumen_AU
dc.subjectfrontotemporal dementiaen_AU
dc.titleCerebellar Atrophy and Its Contribution to Cognition in Frontotemporal Dementiasen_AU
dc.typeArticleen_AU
dc.subject.asrc110904en_AU
dc.subject.asrc170101en_AU
dc.identifier.doi10.1002/ana.25271
dc.type.pubtypePost printen_AU


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