Addenbrooke’s Cognitive Examination III: Psychometric Characteristics and Relations to Functional Ability in Dementia
Field | Value | Language |
dc.contributor.author | So, Matthew | |
dc.contributor.author | Foxe, David | |
dc.contributor.author | Kumfor, Fiona | |
dc.contributor.author | Murray, Cynthia | |
dc.contributor.author | Hsieh, Sharpley | |
dc.contributor.author | Savage, Greg | |
dc.contributor.author | Ahmed, Rebekah M. | |
dc.contributor.author | Burrell, James R. | |
dc.contributor.author | Hodges, John R. | |
dc.contributor.author | Irish, Muireann | |
dc.contributor.author | Piguet, Olivier | |
dc.date.accessioned | 2019-09-06 | |
dc.date.available | 2019-09-06 | |
dc.date.issued | 2018-09-07 | |
dc.identifier.citation | So, M., Foxe, D., Kumfor, F., Murray, C., Hsieh, S., Savage, G., … Piguet, O. (2018). Addenbrooke’s Cognitive Examination III: Psychometric Characteristics and Relations to Functional Ability in Dementia. Journal of the International Neuropsychological Society, 24(8), 854–863. https://doi.org/10.1017/s1355617718000541 | en_AU |
dc.identifier.uri | http://hdl.handle.net/2123/21033 | |
dc.description.abstract | Objectives: The Addenbrooke’s Cognitive Examination (ACE) is a common cognitive screening test for dementia. Here, we examined the relationship between the most recent version (ACE-III) and its predecessor (ACE-R), determined ACE- III cutoff scores for the detection of dementia, and explored its relationship with functional ability. Methods: Study 1 included 199 dementia patients and 52 healthy controls who completed the ACE-III and ACE-R. ACE-III total and domain scores were regressed on their corresponding ACE-R values to obtain conversion formulae. Study 2 included 331 mixed dementia patients and 87 controls to establish the optimal ACE-III cutoff scores for the detection of dementia using receiver operator curve analysis. Study 3 included 194 dementia patients and their carers to investigate the relationship between ACE-III total score and functional ability. Results: Study 1: ACE-III and ACE-R scores differed by ≤1 point overall, the magnitude varying according to dementia type. Study 2: a new lower bound cutoff ACE-III score of 84/100 to detect dementia was identified (compared with 82 for the ACE-R). The upper bound cutoff score of 88/100 was retained. Study 3: ACE-III scores were significantly related to functional ability on the Clinical Dementia Rating Scale across all dementia syndromes, except for semantic dementia. Conclusions: This study represents one of the largest and most clini- cally diverse investigations of the ACE-III. Our results demonstrate that the ACE-III is an acceptable alternative to the ACE-R. In addition, ACE-III performance has broader clinical implications in that it relates to carer reports of functional impairment in most common dementias. (JINS, 2018, 24, 854–863) | en_AU |
dc.language.iso | en | en_AU |
dc.publisher | Cambridge University Press | en_AU |
dc.relation | NHMRC APP1037746; ARC CE11000102; NHMRC-ARC APP1097026; NHMRC-ARC APP1110183; NHMRC APP1072451; ARC FT160100096; NHMRC APP1103258 | en_AU |
dc.rights | This article has been published in a revised form in Journal of the International Neuropsychological Society https://doi.org/10.1017/s1355617718000541. This version is published under a Creative Commons CC-BY-NC-ND. No commercial re-distribution or re-use allowed. Derivative works cannot be distributed. © copyright holder. | en_AU |
dc.subject | Alzheimer’s disease | en_AU |
dc.subject | Frontotemporal dementia | en_AU |
dc.subject | cognitive screening test | en_AU |
dc.subject | Neuropsychological assessment | en_AU |
dc.subject | Clinical Dementia Rating scale | en_AU |
dc.subject | Activities of daily living | en_AU |
dc.title | Addenbrooke’s Cognitive Examination III: Psychometric Characteristics and Relations to Functional Ability in Dementia | en_AU |
dc.type | Article | en_AU |
dc.subject.asrc | 170101 | en_AU |
dc.subject.asrc | 110904 | en_AU |
dc.identifier.doi | 10.1017/S1355617718000541 | |
dc.type.pubtype | Publisher's version | en_AU |
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