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dc.contributor.authorStrikwerda-Brown, Cherie
dc.contributor.authorRamanan, Siddharth
dc.contributor.authorIrish, Muireann
dc.date.accessioned2019-09-05T23:14:38Z
dc.date.available2019-09-05T23:14:38Z
dc.date.issued2019-02-20
dc.identifier.citationStrikwerda-Brown, C., Ramanan, S., & Irish, M. (2019). <p>Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach</p>. Neuropsychiatric Disease and Treatment, Volume 15, 557–573. https://doi.org/10.2147/ndt.s158996en_AU
dc.identifier.urihttp://hdl.handle.net/2123/21032
dc.description.abstractMuch of human interaction is predicated upon our innate capacity to infer the thoughts, beliefs, emotions, and perspectives of others, in short, to possess a “theory of mind” (ToM). While the term has evolved considerably since its inception, ToM encompasses our unique ability to apprehend the mental states of others, enabling us to anticipate and predict subsequent behavior. From a developmental perspective, ToM has been a topic of keen research interest, with numerous studies seeking to explicate the origins of this fundamental capacity and its disruption in developmental disorders such as autism. The study of ToM at the opposite end of the lifespan, however, is paradoxically new born, emerging as a topic of interest in its own right comparatively recently. Here, we consider the unique insights afforded by studying ToM capacity in neurodegenerative disorders. Arguing from a novel, transdiagnostic perspective, we consider how ToM vulnerability reflects the progressive degradation of neural circuits special- ized for an array of higher-order cognitive processes. This mechanistic approach enables us to consider the common and unique neurocognitive mechanisms that underpin ToM dysfunction across neurodegenerative disorders and for the first time examine its relation to behavioral disturbances across social, intimate, legal, and criminal settings. As such, we aim to provide a comprehensive overview of ToM research in neurodegeneration, the resultant challenges for family members, clinicians, and the legal profession, and future directions worthy of exploration.en_AU
dc.language.isoenen_AU
dc.publisherDove Pressen_AU
dc.relationARC CE110001021; NHMRC APP1132764; ARC FT160100096; ARC DP180101584en_AU
dc.rightsThis work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0)en_AU
dc.subjectprefrontal cortexen_AU
dc.subjectsocial cognitionen_AU
dc.subjectmentalizingen_AU
dc.subjectexecutive functionen_AU
dc.subjectdementiaen_AU
dc.subjectempathyen_AU
dc.titleNeurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approachen_AU
dc.typeArticleen_AU
dc.subject.asrc170101en_AU
dc.identifier.doi10.2147/NDT.S158996
dc.type.pubtypePublisher versionen_AU


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