Show simple item record

dc.contributor.authorAhmed, Samrah
dc.contributor.authorIrish, Muireann
dc.contributor.authorLoane, Clare
dc.contributor.authorBaker, Ian
dc.contributor.authorHusain, Masud
dc.contributor.authorThompson, Sian
dc.contributor.authorBlanco-Duque, Cristina
dc.contributor.authorMackay, Clare
dc.contributor.authorZamboni, Giovanna
dc.contributor.authorFoxe, David
dc.contributor.authorHodges, John R.
dc.contributor.authorPiguet, Olivier
dc.contributor.authorButler, Christopher
dc.date.accessioned2019-09-05T22:47:01Z
dc.date.available2019-09-05T22:47:01Z
dc.date.issued2018-03-10
dc.identifier.citationAhmed, S., Irish, M., Loane, C., Baker, I., Husain, M., Thompson, S., … Butler, C. (2018). Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome. NeuroImage: Clinical, 18, 822–834. https://doi.org/10.1016/j.nicl.2018.03.008en_AU
dc.identifier.urihttp://hdl.handle.net/2123/21031
dc.description.abstractPosterior cortical atrophy is a neurodegenerative syndrome characterised by progressive disruption of visual and perceptual processing, associated with atrophy in the parieto-occipital cortex. Current diagnostic criteria de- scribe relative sparing of episodic memory function, but recent findings suggest that anterograde memory is often impaired. Whether these deficits extend to remote memory has not been addressed. A large body of evi- dence suggests that the recollection of an autobiographical event from the remote past coincides with the successful retrieval of visual images. We hypothesised that the profound visual processing deficits in posterior cortical atrophy would result in impaired autobiographical memory retrieval. Fourteen posterior cortical atrophy patients, eighteen typical Alzheimer's disease patients and twenty-eight healthy controls completed the Autobiographical Interview. Autobiographical memory in posterior cortical atrophy was characterised by a striking loss of internal, episodic detail relative to controls and to same extent as typical Alzheimer's disease patients, in conjunction with an increase in external details tangential to the memory described. The memory narratives of posterior cortical atrophy patients showed a specific reduction in spatiotemporal and perceptual detail. Voxel-based morphometry analysis revealed atrophy of the parieto-occipital cortices in posterior cortical atrophy but relatively spared hippocampi bilaterally, compared with characteristic atrophy of the medial tem- poral lobes in typical Alzheimer's disease. Analysis of brain regions showing posterior cortical atrophy-specific atrophy revealed a correlation between perceptual details in autobiographical memory and grey matter density in the right precuneus. This study demonstrates remote memory impairment in posterior cortical atrophy despite relatively preserved medial temporal lobe structures. The results demonstrate, for the first time, profound au- tobiographical memory impairment in PCA and suggest that this is driven by the well-recognised deficits in higher-order visual processing. The findings are discussed in the context of posterior parietal contributions to imagery and memory, and the clinical implications of autobiographical memory impairment for diagnostic and management protocols in posterior cortical atrophy.en_AU
dc.language.isoenen_AU
dc.publisherElsevieren_AU
dc.relationARC FT160100096; NHMRC APP1103258; NHMRC APP1037746; ARC CE110001021en_AU
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).en_AU
dc.subjectPosterior cortical atrophyen_AU
dc.subjectAutobiographical memoryen_AU
dc.subjectVisual imageryen_AU
dc.subjectAlzheimer's diseaseen_AU
dc.titleAssociation between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndromeen_AU
dc.typeArticleen_AU
dc.subject.asrc170101en_AU
dc.subject.asrc110904en_AU
dc.identifier.doi10.1016/j.nicl.2018.03.008
dc.type.pubtypePublisher versionen_AU


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record