Faculty of Science: Recent submissions
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A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family
Published 2018-09-12Ants (Hymenoptera: Formicidae) are diverse and ubiquitous, and their ability to sting is familiar to many of us. However, their venoms remain largely unstudied. We provide the first comprehensive characterization of a ...Open AccessArticle -
Total Synthesis of Glycinocins A−C
Published 2017-09-15The glycinocins are a class of calcium-dependent, acidic cyclolipopeptide antibiotics structurally related to the clinically approved daptomycin. Herein, we describe a divergent total synthesis of glycinocins A–C, which ...Open AccessArticle -
Native Chemical Ligation−Photodesulfurization in Flow
Published 2018-05-24Native chemical ligation (NCL) combined with desulfurization chemistry has revolutionized the way in which large polypeptides and proteins are accessed by chemical synthesis. Herein, we outline the use of flow chemistry ...Open AccessArticle -
Construction of Challenging Proline−Proline Junctions via 2 Diselenide−Selenoester Ligation Chemistry
Published 2018-09-21Polyproline sequences are highly abundant in prokaryotic and eukaryotic proteins, where they serve as key components of secondary structure. To date, construction of the proline–proline motif has not been possible owing ...Open AccessArticle -
Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials
Published 2019-05-07A library of analogues of the cyanobacterium-derived depsipeptide natural product gallinamide A were designed and prepared using a highly efficient and convergent synthetic route. Analogues were shown to exhibit potent ...Open AccessArticle