Faculty of Science: Recent submissions
-
Histone Deacetylase 2 (HDAC2) Inhibitors Containing Boron
Published 2020Histone deacetylase enzymes (HDACs) are responsible for the global silencing of tumour‐suppressor genes. Treatment with a histone deacetylase inhibitor (HDACi) can reverse this process and restore normal cell function. ...Open AccessArticle -
Gadolinium theranostics for the diagnosis and treatment of cancer
Published 2021According to the World Health Organization (WHO), there were 18.1 million new cancer cases and 9.6 million cancer deaths reported worldwide in 2018. These numbers are expected to rise over the next decade, and the ...Open AccessArticle -
Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes
Published 2021The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma ...Open AccessArticle -
Fluoride binding by an anionic receptor: tuning the acidity of amide NH groups for basic anion hydrogen bonding and recognition
Published 2019Here we report a family of bis-amide receptors for anion binding that contain carboxylic acid groups vicinal to the amide function. Deprotonation of the carboxylic acids decreases the acidity of amide NHs, switching on ...Open AccessArticle -
Supramolecular transmembrane anion transport: new assays and insights
Published 2018Transmembrane anion transport has been the focus of a number of supramolecular chemistry research groups for a number of years. Much of this research is driven by the biological relevance of anion transport and the search ...Open AccessArticle