Browsing Faculty of Science by subject "030401"
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Anti-Tubercular bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and In Vivo Studies
Published 2018-03-20We recently reported the discovery of non-toxic cyclam-derived compounds that are active against drug-resistant Mycobacterium tuberculosis. In this paper we report exploration of the structure-activity relationship for ...Open AccessArticle -
Cyclobutanone analogues of beta‐lactam antibiotics: beta‐lactamase inhibitors with untapped potential?
Published 2016-12-19Beta‐Lactam antibiotics have been used for many years to treat bacterial infections. However the effective treatment of an increasing range of microbial infections is threatened by bacterial ...Open AccessArticle -
Electronic Lab Notebook for Synthesis of Tuberculosis Drug Leads
Published 2013-01-01A snapshot of an electronic laboratory notebook used to record the synthesis of new small molecules intended for the treatment of tuberculosis. The compounds are synthesised using an oxa-Pictet Spengler reaction, and are ...Open AccessDataset -
Electronic Laboratory Notebook Snapshots for paper entitled Open Source Drug Discovery - Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles
Published 2015-01-01The files are zipped snapshots of the electronic laboratory notebooks (ELNs) used by the Open Source Malaria (OSM) consortium that are relevant to the paper "Open Source Drug Discovery - Highly Potent Antimalarial Compounds ...Open AccessOther -
NMR Data for Synthesis of Spiro Tuberculosis Drug Leads
Published 2014-05-14NMR data supporting Electronic Lab Notebook for Synthesis of Tuberculosis Drug Leads (http://hdl.handle.net/2123/10461), specifically the paper published based on this work. The NMR spectra/data are for the chemical compounds ...Open AccessDataset -
Non-toxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis
Published 2016-05-23Tuberculosis (TB) accounted for 1.5 million deaths in 2014 and new classes of anti-TB drugs are required. We re-port a class of functionalized 1,8-disubstituted cyclam derivatives that display low micromolar activity against ...Open AccessArticle -
Open Source Malaria Consultation
Published 2012-08-20Open online consultation of the Open Source Malaria Consortium. A discussion on the Consortium's Series 1, including decisions on which compounds next to target with chemical synthesis. Relevant structures may be found in ...Open AccessAudiovisual -
Supporting Information - NMR Spectra for Novel Compounds for Open Source Drug Discovery - Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles
Published 2015-12-08NMR spectra for novel compounds associated with submission of paper entitled "Open Source Drug Discovery - Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles".Open AccessOther