• Anti-Tubercular bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and In Vivo Studies 

      Spain, Malcolm; Wong, Joseph K.-H.; Nagalingam, Gayathri; Batten, James M.; Hortle, Elinor; Oehlers, Stefan; Jiang, Xiao Fan; Murage, Hasini E.; Orford, Jack T.; Crisologo, Patrick; Triccas, James A.; Rutledge, Peter J.; Todd, Matthew H.
      Published 2018-03-20
      We recently reported the discovery of non-toxic cyclam-derived compounds that are active against drug-resistant Mycobacterium tuberculosis. In this paper we report exploration of the structure-activity relationship for ...
      Open Access
      Article
    • Non-toxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis 

      Yu, Mingfeng; Nagalingam, Gayathri; Ellis, Samantha; Martinez, Elena; Sintchenko, Vitali; Spain, Malcolm; Rutledge, Peter J; Todd, Matthew H; Triccas, James A.
      Published 2016-05-23
      Tuberculosis (TB) accounted for 1.5 million deaths in 2014 and new classes of anti-TB drugs are required. We re-port a class of functionalized 1,8-disubstituted cyclam derivatives that display low micromolar activity against ...
      Open Access
      Article