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dc.contributor.authorTsai, VWW
dc.contributor.authorMacia, L
dc.contributor.authorJohnen, H
dc.contributor.authorKuffner, T
dc.contributor.authorManadhar, R
dc.contributor.authorBeck Jorgensen, S
dc.contributor.authorLee-Ng, KKM
dc.contributor.authorZhang, HP
dc.contributor.authorWu, L
dc.contributor.authorMarquis, CP
dc.contributor.authorJiang, L
dc.contributor.authorHusaini, Y
dc.contributor.authorLin, S
dc.contributor.authorHerzog, H
dc.contributor.authorBrown, DA
dc.contributor.authorSainsbury, Amanda
dc.contributor.authorBreit, SN
dc.date.accessioned2017-01-03
dc.date.available2017-01-03
dc.date.issued2013-02-01
dc.identifier.citationTsai VW-W, Macia L, Johnen H, et al. TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator. Morrison C, ed. PLoS ONE. 2013;8(2):e55174. doi:10.1371/journal.pone.0055174.en_AU
dc.identifier.urihttp://hdl.handle.net/2123/16090
dc.description.abstractThe TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of physiologically relevant levels of MIC-1/GDF15 in the regulation of appetite, body weight and basal metabolic rate. MIC-1/GDF15 gene knockout mice (MIC-1−/−) weighed more and had increased adiposity, which was associated with increased spontaneous food intake. Female MIC-1−/− mice exhibited some additional alterations in reduced basal energy expenditure and physical activity, possibly owing to the associated decrease in total lean mass. Further, infusion of human recombinant MIC-1/GDF15 sufficient to raise serum levels in MIC-1−/− mice to within the normal human range reduced body weight and food intake. Taken together, our findings suggest that MIC-1/GDF15 is involved in the physiological regulation of appetite and energy storage.en_AU
dc.language.isoen_AUen_AU
dc.publisherPLoS ONEen_AU
dc.titleTGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulatoren_AU
dc.typeArticleen_AU
dc.type.pubtypePublisher's versionen_AU


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