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dc.contributor.authorGraeber, Manuel B.
dc.contributor.authorChristie, MacDonald J.
dc.date.accessioned2016-06-22
dc.date.available2016-06-22
dc.date.issued2012-04-01
dc.identifier.citationGraeber, M., Christie, M. (2012). Multiple mechanisms of microglia: a gatekeeper's contribution to pain states. Experimental Neurology, 234(2), 255-261.en_AU
dc.identifier.urihttp://hdl.handle.net/2123/15186
dc.description.abstractMicroglia are gatekeepers in the CNS for a wide range of pathological stimuli and they blow the whistle when things go wrong. Collectively, microglia form a CNS tissue alarm system (Kreutzberg's “sensor of pathology”), and their involvement in physiological pain is in line with this function. However, pathological neuropathic pain is characterized by microglial activation that is unwanted and considered to contribute to or even cause tactile allodynia, hyperalgesia and spontaneous pain. Such abnormal microglial behavior seems likely due to an as yet ill-understood disturbance of microglial functions unrelated to inflammation. The idea that microglia have roles in the CNS that differ from those of peripheral macrophages has gained momentum with the discovery of their separate, pre-hematopoietic lineage during embryonic development and their direct interactions with synapses.en_AU
dc.description.sponsorshipNHMRC Grant: 0569927en_AU
dc.language.isoen_AUen_AU
dc.publisherElsevieren_AU
dc.subjectCNS autonomous and specific mechanisms of microglial activationen_AU
dc.subjectDiseased microgliaen_AU
dc.subjectInflammationen_AU
dc.subjectNormal painen_AU
dc.subjectPathological painen_AU
dc.titleMultiple mechanisms of microglia: A gatekeeper's contribution to pain statesen_AU
dc.typeArticleen_AU
dc.identifier.doi10.1016/j.expneurol.2012.01.007
dc.type.pubtypePost-printen_AU
usyd.departmentDiscipline of Pharmacologyen_AU


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