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dc.contributor.authorHens, K
dc.contributor.authorDondorp, W
dc.contributor.authorHandyside, AH
dc.contributor.authorHarper, J
dc.contributor.authorNewson, A.J.
dc.contributor.authorPennings, G
dc.contributor.authorRehmann-Sutter, C
dc.contributor.authorde Wert, G
dc.date.accessioned2014-11-12T01:23:55Z
dc.date.available2014-11-12T01:23:55Z
dc.date.issued2013-03-06
dc.identifier.citationHens, K., Dondorp, W. Handyside, A.H., Harper, J., Newson, A.J. Pennings, G. Rehmann-Sutter, C., de Wert, G. (2013). “Dynamics and Ethics of Comprehensive Preimplantation Genetic Testing. A Review of the Challenges.” Human Reproduction Update. Advance online publication. doi: 10.1093/humupd/dmt009 First published online: March 6, 2013en_AU
dc.identifier.urihttp://hdl.handle.net/2123/12262
dc.description.abstractBACKGROUND: Genetic testing of preimplantation embryos has been used for preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS). Microarray technology is being introduced in both these contexts, and is to be expected that also whole genome sequencing of blastomeres will become possible. The amount of extra information such tests will yield may prove to be beneficial for embryo selection, but also raise various ethical issues. We present an overview of the developments and an agenda-setting exploration of the ethical issues. METHODS: The paper is a joint endeavour by the presenters at an explorative 'campus meeting' organized by the European Society of Human Reproduction and Embryology in cooperation with the department of Health, Ethics & Society of the Maastricht University (The Netherlands). RESULTS: The increasing amount and detail of information that new screening techniques such as microarrays and whole genome sequencing offer does not automatically coincide with an increasing understanding of the prospects of an embryo. From a technical point of view, the future of comprehensive embryo testing may go together with developments in preconception carrier screening. From an ethical point of view, the increasing complexity and amount of information yielded by comprehensive testing techniques will lead to challenges to the principle of reproductive autonomy and the right of the child to an open future, and may imply a possible larger responsibility of the clinician towards the welfare of the future child. “Smart combinations” of preconception carrier testing and embryo testing may solve some of these ethical questions but could introduce others. CONCLUSION: As comprehensive testing techniques are entering the IVF clinic, there is a need for a thorough rethinking of traditional ethical paradigms regarding medically assisted reproduction.en_AU
dc.description.sponsorshipThis article was written by Dr Ainsley Newson during the time of her employment with the University of Bristol, UK (2006-2012). Self-archived in the Sydney eScholarship Repository with permission of Bristol University, Sept 2014.en_AU
dc.language.isoenen_AU
dc.publisherOUPen_AU
dc.titleDynamics and Ethics of Comprehensive Preimplantation Genetic Testing. A Review of the Challengesen_AU
dc.typeArticleen_AU
dc.identifier.doi10.1093/humupd/dmt009
dc.type.pubtypePost-printen_AU


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