Browsing by author "Turville, Stuart"
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Antiviral cyclic peptides targeting the main protease of SARS-CoV-2
Johansen-Leete, Jason; Ullrich, Sven; Fry, Sarah E.; Frkic, Rebecca; Bedding, Max J.; Aggarwal, Anupriya; Ashhurst, Anneliese S.; Ekanayake, Kasuni B.; Mahawaththa, Mithun C.; Sasi, Vishnu M.; Luedtke, Stephanie; Ford, Daniel J.; O'Donoghue, Anthony J.; Passioura, Toby; Larance, Mark; Otting, Gottfried; Turville, Stuart; Jackson, Colin J.; Nitsche, Christoph; Payne, Richard J.Published 2022Antivirals that specifically target SARS-CoV-2 are needed to control the COVID-19 pandemic. The main protease (Mpro) is essential for SARS-CoV-2 replication and is an attractive target for antiviral development. Here we ...Article -
Discovery of Antiviral Cyclic Peptides Targeting the Main Protease of SARS-CoV-2 via mRNA Display
Johansen-Leete, Jason; Ullrich, Sven; Fry, Sarah E.; Frkic, Rebecca; Bedding, Max J.; Aggarwal, Anupriya; Ashhurst, Anneliese S.; Ekanayake, Kasuni B.; Mahawaththa, Mithun C.; Sasi, Vishnu M.; Passioura, Toby; Larance, Mark; Otting, Gottfried; Turville, Stuart; Jackson, Colin J.; Nitsche, Christoph; Payne, Richard J.Published 2021Abstract Antivirals that specifically target SARS-CoV-2 are needed to control the COVID-19 pandemic. The main protease (M pro ) is essential for SARS-CoV-2 replication and is an attractive target for antiviral development. ...Preprint -
Discovery of Cyclic Peptide Ligands to the SARS-CoV_2 Spike Protein Using mRNA Display
Norman, Alexander; Franck, Charlotte; Christie, Mary; Hawkins, Paige M. E.; Patel, Karishma; Ashhurst, Anneliese S.; Aggarwal, Anupriya; Low, Jason K. K.; Siddiquee, Rezwan; Ashley, Caroline L.; Steain, Megan; Triccas, James A.; Turville, Stuart; Mackay, Joel P.; Passioura, Toby; Payne, Richard J.Published 2021The COVID-19 pandemic, caused by SARS-CoV-2, has led to substantial morbidity, mortality, and disruption globally. Cellular entry of SARS-CoV-2 is mediated by the viral spike protein, and affinity ligands to this surface ...Article -
Immunisation of ferrets and mice with recombinant SARS-CoV-2 spike protein formulated with Advax-SM adjuvant protects against COVID-19 infection
Li, Lei; Honda-Okubo, Yoshikazu; Huang, Ying; Jang, Hyesun; Carlock, Michael A; Baldwin, Jeremy; Piplani, Sakshi; Bebin-Blackwell, Anne G; Forgacs, David; Sakamoto, Kaori; Stella, Alberto; Turville, Stuart; Chataway, Tim; Colella, Alex; Triccas, Jamie; Ross, Ted M; Petrovsky, NikolaiPublished 2021The development of a safe and effective vaccine is a key requirement to overcoming the COVID-19 pandemic. Recombinant proteins represent the most reliable and safe vaccine approach but generally require a suitable adjuvant ...Article -
Immunisation of ferrets and mice with recombinant SARS-CoV-2 spike protein formulated with Advax-SM adjuvant protects against COVID-19 infection
Li, Lei; Honda-Okubo, Yoshikazu; Huang, Ying; Jang, Hyesun; Carlock, Michael A.; Baldwin, Jeremy; Piplani, Sakshi; Bebin-Blackwell, Anne G.; Forgacs, David; Sakamoto, Kaori; Stella, Alberto; Turville, Stuart; Chataway, Tim; Colella, Alex; Triccas, Jamie; Ross, Ted M; Petrovsky, NikolaiPublished 2021The development of a safe and effective vaccine is a key requirement to overcoming the COVID-19 pandemic. Recombinant proteins represent the most reliable and safe vaccine approach but generally require a suitable adjuvant ...Preprint -
Immunizations with diverse sarbecovirus receptor binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability
Burnett, Deborah L; Jackson, Katherine J L; Langley, David B; Aggrawal, Anupria; Stella, Alberto Ospina; Johansen, Matt D; Balachandran, Harikrishnan; Lenthall, Helen; Rouet, Romain; Walker, Gregory; Saunders, Bernadette M; Singh, Mandeep; Li, Hui; Henry, Jake Y; Jackson, Jennifer; Stewart, Alastair G; Witthauer, Franka; Spence, Matthew A; Hansbro, Nicole G; Jackson, Colin; Schofield, Peter; Milthorpe, Claire; Martinello, Marianne; Schulz, Sebastian R; Roth, Edith; Kelleher, Anthony; Emery, Sean; Britton, Warwick J; Rawlinson, William D; Karl, Rudolfo; Schäfer, Simon; Winkler, Thomas H; Brink, Robert; Bull, Rowena A; Hansbro, Philip M; Jäck, Hans-Martin; Turville, Stuart; Christ, Daniel; Goodnow, Christopher CPublished 2021Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy. Second-generation vaccines will need to elicit neutralizing antibodies against sites that are evolutionarily conserved across the ...Article -
Long-term persistence of neutralizing memory B cells in SARS-CoV-2
Bull, Rowena; Abayasingam, Arunasingam; Balachandran, Harikrishnan; Agapiou, David; Rodrigo, Chaturaka; Keoshkerian, Elizabeth; Li, Hui; Brasher, Nicholas; Christ, Daniel; Rouet, Romain; Burnett, Deborah; Grubor-Bauk, Branka; Rawlinson, William; Turville, Stuart; Aggarwal, Anupriya; Brilot, Fabienne; Mina, Michael; Post, Jeffrey; Hudson, Bernard; Gilroy, Nicky; Dwyer, Dominic; Sasson, Sarah; Tea, Fiona; Pilli, Deepti; Tedla, Nicodemus; Lloyd, Andrew; Martinello, MariannePublished 2020Considerable concerns relating to the duration of protective immunity against SARS-CoV-2 have been raised, with evidence of antibody titres declining rapidly after infection and reports of reinfection. Here we monitored ...Preprint -
LRRC15 suppresses SARS-CoV-2 infection and controls collagen production
Loo, Lipin; Waller, Matthew A.; Cole, Alexander J.; Stella, Alberto Ospina; Moreno, Cesar L.; Denes, Christopher E.; Hamoudi, Zina; Chung, Felicity; Aggarwal, Anupriya; Low, Jason K. K.; Patel, Karishma; Siddique, Rezwan; Mackay, Joel; Turville, Stuart; Hesselson, Daniel; Neely, G. GregoryPublished 2021The coronavirus pandemic has given everyone in society an education on the harms of spread of respiratory illness. Young healthy athletes are far less likely to suffer severe adverse consequences of viral illnesses than ...Preprint -
LRRC15 suppresses SARS-CoV-2 infection and controls collagen production
Loo, Lipin; Waller, Matthew; Cole, Alexander; Stella, Alberto; Moreno, Cesar; Denes, Christopher; Hamoudi, Zina; Chung, Felicity; Aggarwal, Anupriya; Low, Jason; Patel, Karishma; Siddiquee, Rezwan; Mackay, Joel; Turville, Stuart; Hesselson, Daniel; Neely, G.Published 2022Although ACE2 is the primary receptor for SARS-CoV-2 infection, a systematic assessment of factors controlling SARS-CoV-2 host interactions has not been described. Here we used whole genome CRISPR activation to identify ...Preprint -
Maintenance of Broad Neutralising Antibodies and Memory B Cells 12 Months Post-Infection Is Predicted by SARS-CoV-2 Specific CD4+ T Cell Responses
Balachandran, Harikrishnan; Phetsouphanh, Chansavath; Agapiou, David; Adhikari, Anurag; Rodrigo, Chaturaka; Hammoud, Mohamed; Shrestha, Lok Bahadur; Keoshkerian, Elizabeth; Gupta, Money; Turville, Stuart; Christ, Daniel; King, Cecile; Sasson, Sarah; Bartlett, Adam; Grubor-Bauk, Branka; Rawlinson, William; Aggarwal, Anupriya; Stella, Alberto Ospina; Klemm, Vera; Mina, Michael M.; Post, Jeffrey J.; Hudson, Bernard; Gilroy, Nicky; Konecny, Pam; Ahlenstiel, Golo; Dwyer, Dominic; Sorrell, Tania C.; Kelleher, Anthony; Tedla, Nicodemus; Lloyd, Andrew R.; Martinello, Marianne; Bull, Rowena AnnePublished 2021Understanding the long-term maintenance of SARS-CoV-2 immunity is critical for prediction of protection against reinfection. In a cohort of 24 participants, the association of disease severity and early immunological ...Preprint -
Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses
Balachandran, Harikrishnan; Phetsouphanh, Chansavath; Agapiou, David; Adhikari, Anurag; Rodrigo, Chaturaka; Hammoud, Mohamed; Shrestha, Lok Bahadur; Keoshkerian, Elizabeth; Gupta, Money; Turville, Stuart; Christ, Daniel; King, Cecile; Sasson, Sarah C.; Bartlett, Adam; Grubor-Bauk, Branka; Rawlinson, William; Aggarwal, Anupriya; Stella, Alberto Ospina; Klemm, Vera; Mina, Michael M.; Post, Jeffrey J.; Hudson, Bernard; Gilroy, Nicky; Konecny, Pam; Ahlenstiel, Golo; Dwyer, Dominic E.; Sorrell, Tania C.; Kelleher, Anthony; Tedla, Nicodemus; Lloyd, Andrew R.; Martinello, Marianne; Bull, Rowena A.; Group, COSIN StudyPublished 2022Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection. In an age- and gender-matched cohort of 24 ...Article -
Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice
Ashhurst, Anneliese; Johansen, Matt; Maxwell, Joshua; Ashley, Caroline; Aggarwal, Anupriya; Siddiquee, Rezwan; Miemczyk, Stefan; Nguyen, Duc; Mackay, Joel; Counoupas, Claudio; Byrne, Scott; Turville, Stuart; Steain, Megan; Triccas, James; Hansbro, Philip; Payne, Richard; Britton, WarwickPublished 2022Current vaccines against SARS-CoV-2 substantially reduce mortality, but protection against infection is less effective. Enhancing immunity in the respiratory tract, via mucosal vaccination, may provide protection against ...Preprint -
Patients with treated indolent lymphomas immunized with BNT162b2 have reduced anti‐spike neutralizing IgG to SARS‐CoV‐2 variants, but preserved antigen‐specific T cell responses
Beaton, Brendan; Sasson, Sarah C.; Rankin, Katherine; Raedemaeker, Juliette; Wong, Alexander; Hastak, Priyanka; Phetsouphanh, Chansavath; Warden, Andrew; Klemm, Vera; Munier, C. Mee Ling; Hoppe, Alexandra Carey; Tea, Fiona; Pillay, Aleha; Stella, Alberto Ospina; Aggarwal, Anupriya; Lavee, Orly; Caterson, Ian D.; Turville, Stuart; Kelleher, Anthony D.; Brilot, Fabienne; Trotman, JudithPublished 2022Patients with indolent lymphoma undertaking recurrent or continuous B cell suppression are at risk of severe COVID-19. Patients and healthy controls (HC; N=13) received 2 doses of BNT162b2: Follicular Lymphoma (FL; N=35) ...Article -
Persistent high‐level shedding of cultivable SARS‐CoV‐2 Delta virus 33 days after onset of COVID‐19 in a hospitalized patient with pneumonia
Kim, Ki Wook; Wang, Xinye; Adhikari, Anurag; Yeang, Malinna; Jenkins, Frances; Naing, Zin; Walker, Gregory J.; Foster, Charles S. P.; Stelzer‐Braid, Sacha; Deveson, Ira; Craig, Maria E.; Tedla, Nicodemus; Bull, Rowena A.; Martinello, Marianne; Pinto, Angie N.; Chan, Raymond; Turville, Stuart; Rawlinson, William D.; Hal, SebastiaanPublished 2022Article -
Potent Anti-SARS-CoV_2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L
Ashhurst, Anneliese S.; Tang, Arthur H.; Fajtova_, Pavla; Yoon, Michael C.; Aggarwal, Anupriya; Bedding, Max J.; Stoye, Alexander; Beretta, Laura; Pwee, Dustin; Drelich, Aleksandra; Skinner, Danielle; Li, Linfeng; Meek, Thomas D.; McKerrow, James H.; Hook, Vivian; Tseng, Chien-Te; Larance, Mark; Turville, Stuart; Gerwick, William H.; O’Donoghue, Anthony J.; Payne, Richard J.Published 2021Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a promising drug target for novel antivirals against SARS-CoV-2. The marine natural product gallinamide A and several synthetic ...Article
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