Browsing by author "Rutledge, Peter J"
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Combined “Dual” Absorption and Fluorescence Smartphone Spectrometers
Hossain, Md Arafat; Canning, John; Ast, Sandra; Cook, Kevin; Rutledge, Peter J; Jamalipour, AbbasPublished 2015-04-08A dual absorption and fluorescence smartphone spectrometer is demonstrated. The optical sources are the white flash LED, a blue LED λ = 450 nm and a UV LED at 370 nm, the latter two placed at 90º. Detection was carried out ...Open AccessArticle, Letter -
Cyclobutanone analogues of beta‐lactam antibiotics: beta‐lactamase inhibitors with untapped potential?
Devi, Prarthana; Rutledge, Peter JPublished 2016-12-19Beta‐Lactam antibiotics have been used for many years to treat bacterial infections. However the effective treatment of an increasing range of microbial infections is threatened by bacterial ...Open AccessArticle -
A Fluorescent “Allosteric Scorpionand” Complex Visualizes a Biological Recognition Event
Yu, Mingfeng; Yu, Qun; Rutledge, Peter J; Todd, MatthewPublished 2013-01-09A new class of fluorescent reporter is described and used to visualize the biotin/avidin binding interaction. Derivatives of the azamacrocycle cyclam that contain a pendant naphthalimide dye are inherently fluorescent when ...Open AccessArticle, Letter -
Molecular Switches for any pH: A Systematic Study of the Versatile Coordination Behaviour of Cyclam Scorpionands
Lau, Yu Heng; Clegg, Jack K; Price, Jason R; Macquart, Rene B; Todd, Matthew H; Rutledge, Peter JPublished 2017-10-19Molecular switches have many potential applications in nanoscience and biomedicine. Transition metal complexes that can be switched from an inert, unreactive state to a catalytically active one by a simple change in ...Open AccessArticle, Letter -
Non-toxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis
Yu, Mingfeng; Nagalingam, Gayathri; Ellis, Samantha; Martinez, Elena; Sintchenko, Vitali; Spain, Malcolm; Rutledge, Peter J; Todd, Matthew H; Triccas, James A.Published 2016-05-23Tuberculosis (TB) accounted for 1.5 million deaths in 2014 and new classes of anti-TB drugs are required. We re-port a class of functionalized 1,8-disubstituted cyclam derivatives that display low micromolar activity against ...Open AccessArticle -
Selective displacement of a scorpionand triazole ligand from metallocyclam complexes visualised using NMR spectroscopy.
Wong, Joseph; Proschogo, Nicholas; Todd, Matthew H; Rutledge, Peter JPublished 2017-01-15Target-activated metal complexes (TAMCs) – complexes that remain benign until reaching a specific biomolecular target, binding to which then affects structural change that turns on cytotoxicity or other activity – hold ...Open AccessArticle -
Substrate range and enantioselectivity of epoxidation reactions mediated by the ethene-oxidising Mycobacterium strain NBB4
Cheung, Samantha; McCarl, Victoria; Holmes, Andrew; Coleman, Nicholas; Rutledge, Peter JPublished 2012-03-14Mycobacterium strain NBB4 is an ethene-oxidizing micro-organism isolated from the estuarine sediments of Botany Bay. In pursuit of new systems for biocatalytic epoxidation, we report the capacity of strain NBB4 to convert ...Open AccessArticle -
Using Click Chemistry to Tune the Properties and the Fluorescence Response Mechanism of Structurally Similar Probes for Metal Ions
Ast, Sandra; Kuke, Stefanie; Rutledge, Peter J; Todd, Matthew HPublished 2014-12-05Four cyclam-based fluorescent molecular probes were prepared using ‘click’ chemistry and investigated to determine the effect of the triazole connectivity and fluorophore substitution on photophysical properties and metal ...Open AccessArticle
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