Browsing by author "Radom, Leo"
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Accelerated Protein Synthesis via One-Pot Ligation-Deselenization Chemistry
Mitchell, Nicholas J.; Sayers, Jessica; Kulkarni, Sameer S.; Clayton, Daniel; Goldys, Anna M.; Ripoll-Rozada, Jorge; Pereira, Pedro Jose Barbosa; Chan, Bun; Radom, Leo; Payne, Richard J.Published 2017-05-11Peptide ligation chemistry has revolutionized protein science by facilitating access to synthetic proteins. Here, we describe the development of additive-free ligation-deselenization chemistry at β-selenoaspartate and ...Open AccessArticle -
Chemoselective Peptide Ligation–Desulfurization Chemistry at Aspartate
Thompson, Robert E.; Chan, Bun; Radom, Leo; Jolliffe, Katrina A.; Payne, Richard J.Published 2013-07-24Asp‐ecially useful : A synthetic β‐mercapto aspartate residue facilitates the rapid ligation to a range of peptide thioesters. Following the ligation reaction (and without purification), chemoselective desulfurization of ...Open AccessArticle -
Photographic Autobiography of Leo Radom
Radom, LeoPublished 2019-11-04This dataset will contain an extensive set of photos that will complement the scientific autobiography of Leo Radom. The latter is being published by the American Chemical Society within a virtual special issue of the ...Dataset -
Rapid Additive-Free Selenocystine–Selenoester Peptide Ligation
Mitchell, Nicholas J.; Malins, Lara R.; Liu, Xuyu; Thompson, Robert E.; Chan, Bun; Radom, Leo; Payne, Richard J.Published 2015-10-21We describe an unprecedented reaction between peptide selenoesters and peptide dimers bearing N-terminal selenocystine that proceeds in aqueous buffer to afford native amide bonds without the use of additives. The ...Open AccessArticle
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