Browsing by author "Pérez-Tomás, Ricardo"
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Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations
Marques, Igor; Costa, Pedro M.R.; Miranda, Margarida Q.; Busschaert, Nathalie; Howe, Ethan N.W.; Clarke, Harriet J.; Haynes, Cally J.E.; Kirby, Isabelle L.; Rodilla, Ananda M.; Pérez-Tomás, Ricardo; Gale, Philip A.; Félix, VítorPublished 2018-01-01A comprehensive experimental and theoretical investigation of the transmembrane chloride transport promoted by four series of squaramide derivatives, with different degrees of fluorination, number of convergent N–H binding ...Open AccessArticle -
Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations
Marques, Igor; Costa, Pedro M.R.; Miranda, Margarida Q.; Busschaert, Nathalie; Howe, Ethan N.W.; Clarke, Harriet J.; Haynes, Cally J.E.; Kirby, Isabelle L.; Rodilla, Ananda M.; Pérez-Tomás, Ricardo; Gale, Philip A.; Félix, VítorPublished 2018-06-29A comprehensive experimental and theoretical investigation of the transmembrane chloride transport promoted by four series of squaramide derivatives, with different degrees of fluorination, number of convergent N–H binding ...Open AccessArticle -
Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents
Jowett, Laura A.; Howe, Ethan N.W.; Soto-Cerrato, Vanessa; Van Rossom, Wim; Pérez-Tomás, Ricardo; Gale, Philip A.Published 2017-01-01Prodigiosin is one of the most potent anion transporters in lipid bilayer membranes reported to date. Inspired by the structure of this natural product, we have recently designed and synthesised a new class of H+/Cl− ...Open AccessArticle -
Stimuli-responsive cycloaurated ‘OFF-ON’ switchable anion transporters
Fares, Mohamed; Wu, Xin; Ramesh, Deepthi; Lewis, William; Keller, Paul A.; Howe, Ethan N.W.; Pérez-Tomás, Ricardo; Gale, Philip A.Published 2020-01-01Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes ...Open AccessArticle
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