Browsing by author "Nguyen, DT"
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The accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom prostate motion measurements during patient treatments.
Kim, JH; Nguyen, DT; Booth, JT; Huang, CY; Fuangrod, T; Poulsen, P; O'Brien, R; Caillet, V; Eade, T; Kneebone, A; Keall, PPublished 2018-02-01BACKGROUND AND PURPOSE: To perform a quantitative analysis of the accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom (6DoF) prostate motion measurements during treatments. MATERIAL ...Open AccessArticle -
The Accuracy and Precision of the KIM Motion Monitoring System Used in the Multi-Institutional TROG 15.01 Stereotactic Prostate Ablative Radiotherapy With KIM (SPARK) Trial
Hewson, E; Nguyen, DT; O'Brien, R; Kim, J-H; Montanaro, T; Moodie, T; Greer, P; Hardcastle, N; Eade, T; Kneebone, A; Hruby, G; Hayden, A; Turner, S; Siva, S; Tai, K-H; Hunter, P; Sams, J; Poulsen, P; Booth, J; Martin, J; Keall, PPublished 2019-01-01Purpose: Kilovoltage intrafraction monitoring (KIM) allows for real-time image guidance for tracking tumor motion in six-degrees-of-freedom (6DoF) on a standard linear accelerator. This study assessed the geometric accuracy ...Open AccessArticle -
Adapting to the motion of multiple independent targets using multileaf collimator tracking for locally advanced prostate cancer: Proof of principle simulation study.
Hewson, E; Ge, Y; O'Brien, R; Roderick, S; Bell, L; Poulsen, P; Eade, T; Booth, J; Keall, P; Nguyen, DTPublished 2021Purpose: For patients with locally advanced cancer, multiple targets are treated simultaneously with radiotherapy. Differential motion between targets can compromise the treatment accuracy, yet there are currently no methods ...Open AccessArticle -
An augmented correlation framework for the estimation of tumour translational and rotational motion during external beam radiotherapy treatments using intermittent monoscopic x-ray imaging and an external respiratory signal.
Nguyen, DT; Booth, JT; Caillet, V; Hardcastle, N; Briggs, A; Hadad, C; Eade, T; O'Brien, R; Keall, PPublished 2018-10-01Increasing evidence shows that intrafraction tumour motion monitoring must include both six degrees of freedom (6DoF): 3D translations and 3D rotations. Existing real-time algorithms for 6DoF target motion estimation require ...Open AccessArticle -
A comparison of gantry-mounted x-ray-based real-time target tracking methods.
Montanaro, T; Nguyen, DT; Keall, P; Booth, J; Caillet, V; Eade, T; Hadad, C; Shieh, CCPublished 2018-03-01PURPOSE: Most modern radiotherapy machines are built with a 2D kV imaging system. Combining this imaging system with a 2D-3D inference method would allow for a ready-made option for real-time 3D tumor tracking. This work ...Open AccessArticle -
Deep learning enables MV-based real-time image guided radiation therapy for prostate cancer patients.
Chrystall, D; Mylonas, A; Hewson, E; Martin, J; Keall, P; Booth, J; Nguyen, DTPublished 2023Objective. Using MV images for real-time image guided radiation therapy (IGRT) is ideal as it does not require additional imaging equipment, adds no additional imaging dose and provides motion data in the treatment beam ...Open AccessArticle -
Dose-based optimisation for multi-leaf collimator tracking during radiation therapy.
Mejnertsen, L; Hewson, E; Nguyen, DT; Booth, J; Keall, PPublished 2021Motion in the patient anatomy causes a reduction in dose delivered to the target, while increasing dose to healthy tissue. Multi-leaf collimator (MLC) tracking has been clinically implemented to adapt dose delivery to ...Open AccessArticle -
Dosimetric impact of intrafraction rotations in stereotactic prostate radiotherapy: A subset analysis of the TROG 15.01 SPARK trial.
Wolf, J; Nicholls, J; Hunter, P; Nguyen, DT; Keall, P; Martin, JPublished 2019-01-01Background and purpose: Accurate delivery of radiotherapy is critical to achieve optimal treatment outcomes. Interfraction translational IGRT is now standard, and intrafraction motion management is becoming accessible. ...Open AccessArticle -
The first clinical implementation of a real-time six degree of freedom target tracking system during radiation therapy based on Kilovoltage Intrafraction Monitoring (KIM).
Nguyen, DT; O'Brien, R; Kim, JH; Huang, CY; Wilton, L; Greer, P; Legge, K; Booth, JT; Poulsen, PR; Martin, J; Keall, PPublished 2017-04-01PURPOSE: We present the first clinical implementation of a real-time six-degree of freedom (6DoF) Kilovoltage Intrafraction Monitoring (KIM) system which tracks the cancer target translational and rotational motions during ...Open AccessArticle -
The first clinical implementation of real-time image-guided adaptive radiotherapy using a standard linear accelerator.
Keall, P; Nguyen, DT; O'Brien, R; Caillet, V; Hewson, E; Poulsen, PR; Bromley, R; Bell, L; Eade, T; Kneebone, A; Martin, J; Booth, JTPublished 2018-04-01PURPOSE: Until now, real-time image guided adaptive radiation therapy (IGART) has been the domain of dedicated cancer radiotherapy systems. The purpose of this study was to clinically implement and investigate real-time ...Open AccessArticle -
In Reply to Dahele and Verbakel
Keall, P; Nguyen, DT; O'Brien, RT; Zhang, P; Bertholet, J; Poulsen, PRPublished 2019-01-01N/AOpen AccessArticle, Letter -
An interdimensional correlation framework for real-time estimation of six degree of freedom target motion using a single x-ray imager during radiotherapy.
Nguyen, DT; Bertholet, J; Kim, JH; O'Brien, R; Booth, JT; Poulsen, PR; Keall, PPublished 2017-12-01Increasing evidence suggests that intrafraction tumour motion monitoring needs to include both 3D translations and 3D rotations. Presently, methods to estimate the rotation motion require the 3D translation of the target ...Open AccessArticle -
Optimising multi-target multileaf collimator tracking using real-time dose for locally advanced prostate cancer patients.
Hewson, E; Nguyen, DT; Le, A; Booth, JT; Keall, P; Mejnertsen, LPublished 2022Objective. The accuracy of radiotherapy for patients with locally advanced cancer is compromised by independent motion of multiple targets. To date, MLC tracking approaches have used 2D geometric optimisation where the MLC ...Open AccessArticle -
Pre-treatment and real-time image guidance for a fixed-beam radiotherapy system.
Liu, P; Gardner, M; Heng, SM; Shieh, C-C; Nguyen, DT; Debrot, E; O'Brien, R; Downes, S; Jackson, M; Keall, PPublished 2021Purpose: A radiotherapy system with a fixed treatment beam and a rotating patient positioning system could be smaller, more robust and more cost effective compared to conventional rotating gantry systems. However, patient ...Open AccessArticle -
Quantifying the accuracy and precision of a novel real-time 6 degree-of-freedom kilovoltage intrafraction monitoring (KIM) target tracking system.
Kim, JH; Nguyen, DT; Huang, CY; Fuangrod, T; Caillet, V; O'Brien, R; Poulsen, P; Booth, J; Keall, PPublished 2017-06-01Target rotation can considerably impact the delivered radiotherapy dose depending on the tumour shape. More accurate tumour pose during radiotherapy treatment can be acquired through tracking in 6 degrees-of-freedom (6 ...Open AccessArticle -
Review of Real-Time 3-Dimensional Image Guided Radiation Therapy on Standard-Equipped Cancer Radiation Therapy Systems: Are We at the Tipping Point for the Era of Real-Time Radiation Therapy?
Keall, P; Nguyen, DT; O'Brien, R; Zhang, P; Happersett, L; Bertholet, J; Poulsen, PRPublished 2018-11-15PURPOSE: To review real-time 3-dimensional (3D) image guided radiation therapy (IGRT) on standard-equipped cancer radiation therapy systems, focusing on clinically implemented solutions. METHODS AND MATERIALS: Three groups ...Open AccessArticle -
A six-degree-of-freedom robotic motion system for quality assurance of real-time image-guided radiotherapy.
Alnaghy, S; Kyme, A; Caillet, V; Nguyen, DT; O'Brien, R; Booth, JT; Keall, PPublished 2019-03-21In this study we develop and characterise a six degree-of-freedom (6 DoF) robotic motion system for quality assurance of real-time image-guided radiotherapy techniques. The system consists of a commercially available robotic ...Open AccessArticle -
Technical Note: Real-time image-guided adaptive radiotherapy of a rigid target for a prototype fixed beam radiotherapy system.
Liu, P; Nguyen, DT; Feain, I; O'Brien, R; Keall, P; Booth, JTPublished 2018-10-01PURPOSE: Fixed beam radiotherapy systems utilize couch movement and rotation instead of gantry rotation in order to simplify linear accelerator design. We investigate the ability to deliver fixed beam treatments with the ...Open AccessArticle
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