• Rectangular lattice Boltzmann method using multiple relaxation time collision operator in two and three dimensions 

      Zecevic, Vanja; Kirkpatrick, Michael Philip; Armfield, Steven William
      Published 2020
      We present a lattice Boltzmann (LB) method using a rectangular, non-isotropic lattice based on D2Q9 and D3Q27 velocity sets in two and three dimensions. A second order multi-scale expansion ensures that the scheme correctly ...
      Open Access
      Article
    • Does Upper Airway Deformation Affect Drug Deposition? 

      Cheng, Shaokoon; Kourmatzis, Agisilaos; Mekonnen, Taye; Gholizadeh, Hanieh; Raco, Joel; Tang, Patricia; Chan, Hak-Kim
      Published 2019
      Knowledge that enables the accurate simulation of drug deposition in the human upper airway is necessary to develop robust platforms for efficient drug delivery by inhalation devices. The human upper airway is deformable ...
      Open Access
      Article
    • Potential effects of lingual fats on airway flow dynamics and particle deposition 

      Ma, Bingjie; Kourmatzis, Agisilaos; Zhao, Yongling; Yang, Runyu; Chan, Hak-Kim; Salehi, Fatemeh; Cheng, Shaokoon
      Published 2019
      Fat content on upper airway soft tissue can alter the geometry of the human pharynx, most notably through narrowing of the upper airway at the level of the epiglottis. Despite the important role of the epiglottis during ...
      Open Access
      Article
    • The effects of upper airway tissue motion on airflow dynamics 

      Zhao, Yongling; Raco, Joel; Kourmatzis, Agisilaos; Diasinos, Sammy; Chan, Hak-Kim; Yang, Runyu; Cheng, Shaokoon
      Published 2019
      The human upper airway is not only geometrically complex, but it can also deform dynamically as a result of active muscle contraction and motility during respiration. How the active transformation of the airway geometry ...
      Open Access
      Article
    • Effect of an upstream grid on the fluidization of pharmaceutical carrier powders 

      Elserfy, Khalid; Kourmatzis, Agisilaos; Chan, Hak-Kim; Walenga, Ross; Cheng, Shaokoon
      Published 2020
      The influence of grid generated mixing on the fluidization of pharmaceutical carrier powders 15 is studied in a channel-flow experiment using direct high-speed imaging and particle image 16 velocimetry (PIV). Four different ...
      Open Access
      Article