The relationship between cholesterol crystals, foamy macrophages and haemosiderin in odontogenic cysts
| Field | Value | Language |
| dc.contributor.author | Iqbal, Md. Firoz | |
| dc.date.accessioned | 2009-02-19 | |
| dc.date.available | 2009-02-19 | |
| dc.date.issued | 2008-01-01 | |
| dc.identifier.uri | http://hdl.handle.net/2123/4060 | |
| dc.description | Odontogenic cysts often contain cholesterol clefts, foamy macrophages and haemosiderin deposits. Earlier studies demonstrating correlation between haemosiderin and cholesterol clefts in odontogenic cysts suggest that cholesterol may accumulate in these lesions from degenerate erythrocytes. The amount of cholesterol in erythrocytes, however, is quite small, so that an alternative source of cholesterol from plasma derived low density lipoprotein, similar to that described for atherosclerosis, seems more likely. While foamy macrophages have been proposed as important in the generation of cholesterol clefts in atherosclerosis, no studies have investigated the relationship between foamy macrophages and haemosiderin in odontogenic cysts, while there is also a paucity of information on the relationship between cholesterol clefts and foamy macrophages in such lesions. This thesis describes a histological survey of radicular cysts, dentigerous cysts and odontogenic keratocysts in which the occurrence of haemosiderin, cholesterol clefts and foamy macrophages was recorded and correlated. Contrary to expectations, but nonetheless consistent with the literature, the association between cholesterol clefts and haemosiderin was confirmed. Novel observations were a similar correlation between haemosiderin and foamy macorphages, as well as foamy macorphages and cholesterol clefts in odontogenic cysts. Also, this thesis describes the first spatial analysis of such deposits in odontogenic lesions. Intracellular cholesterol clefts in foamy macorphages were also described for the first time in this thesis. Although data demonstrate a relationship between haemosiderin and lipid deposits, further work is suggested to determine if this is a causal relationship. | en |
| dc.language.iso | en_AU | en |
| dc.rights | Copyright All Rights Reserved | en |
| dc.title | The relationship between cholesterol crystals, foamy macrophages and haemosiderin in odontogenic cysts | en |
| dc.type | Thesis | en |
| usyd.faculty | Faculty of Medicine and Health, Sydney Dental School | en |
| usyd.department | Faculty of Dentistry | en |
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