Sydney Digital Theses (Open Access): Recent submissions
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Revealing the determinants of virus ecology, evolution and emergence in fish
Published 2024Viral diseases emerge when a virus jumps from a donor to a recipient host species. Revealing the determinants of how viruses jump between animals is a question of fundamental importance in infectious disease ecology and ...Open AccessThesis -
Functional and structural characterisation of the glycine transporter 2
Published 2024Modulation of glycinergic neurotransmission is a potential new avenue for the development of clinically viable treatments of neuropathic pain. Inhibition of the glycine transporter 2 has renewed interest with opiranserin ...Open AccessThesis -
Deciphering the role of noradrenergic ascending neuromodulation in large-scale system communication
Published 2024The current thesis investigates the intricate role played by the locus coeruleus noradrenergic system (LC-NA) in shaping adaptive cognitive and neurobiological processes. The LC is the central hub of the ascending ...Open AccessThesis -
Development of Novel Therapy Targeting Autophagy Against Advanced and Chemo-resistant Pancreatic Cancer.
Published 2024Autophagy is a highly conserved recycling process carried out ubiquitously in humans that primarily involves both selective and non-selective degradation of cellular materials ranging from small proteins to organelles as ...Open AccessThesis -
Bionic Ears & Dizziness: Examining the Impact of Cochlear Implantation on Vestibular Function
Published 2024Cochlear implantation (CI) is regarded as an effective and life-changing intervention for individuals with bilateral severe to profound hearing loss. The success of CI has seen an expansion of its candidacy criteria in ...Open AccessThesis