Sydney Digital Theses (Open Access): Recent submissions
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Understanding the role of B cells in the pathogenesis of Inflammatory Bowel Disease
Published 2024Inflammatory Bowel Disease (IBD) is a chronic relapsing-remitting disease comprising of two broad phenotypes: Ulcerative Colitis (UC) and Crohn's Disease (CD). The worldwide prevalence and incidence of IBD is on the rise ...Open AccessThesis -
Correcting CPS1 Deficiency in Primary Human Hepatocytes In Vivo Using AAV Delivered Cell-Cycle Independent Targeted Genome Editing
Published 2024Carbamoyl phosphate synthetase I (CPS1) deficiency is a rare genetic metabolic disorder that impairs nitrogen metabolism. Loss of CPS1 enzyme function can cause neonatal death or intellectual disability. The only treatment ...Open AccessThesis -
“If you want to work, let’s work out how to make this happen”: Supporting young adults experiencing psychosis with their employment
Published 2024Young adults with psychosis want to work, but employment rates remain stubbornly low despite interventions, such as Individual Placement and Support (IPS) and Early Intervention (EI) having evidence to show they can support ...Open AccessThesis -
Local Anticoagulation via Gene Therapy: Towards Preventing Cardioembolic Stroke
Published 2024Cardiac thromboembolism persists as the culprit behind most ischemic strokes; a majority arising from the left atrial appendage. Oral anticoagulants, while effective in preventing stroke, come with an attendant bleeding ...Open AccessThesis -
Intrapulmonary percussive ventilation in critical care and acute care settings
Published 2024Patients in critical care are at risk of pulmonary complications, which may result in impaired respiratory function and poor patient outcomes. Respiratory physiotherapy interventions are routinely employed to treat these ...Open AccessThesis