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dc.contributor.authorAbdul Razak, Muzib
dc.date.accessioned2025-07-18T03:14:57Z
dc.date.available2025-07-18T03:14:57Z
dc.date.issued2025en_AU
dc.identifier.urihttps://hdl.handle.net/2123/34121
dc.descriptionIncludes publication
dc.description.abstractEarly oral cancer (EOC) is defined as patient diagnosed with a T1 or T2 primary and a clinically N0 neck – according to AJCC – TNM staging these are cancers <4 cm in maximum dimension and <10 mm in maximum depth of invasion (DOI) and both clinically/radiologically absent of neck nodal metastases. Traditional treatment is surgery with appropriate resection of the primary and simultaneous excision of upper cervical neck nodes. However, following neck dissection microscopic metastases are present in only 15-20% of T1 and 25-35% of T2 cancers, respectively. Consequently, up to 80% of patients with a T1 cancer and 65% of T2 cancer undergo surgery to the neck with no oncological or survival benefit yet have been exposed to the risks and complications of a neck dissection. Sentinel lymph node biopsy (SLNB) is a novel technique, which can overcome the disadvantages of unnecessary neck surgery. In this procedure a radioactive dye is injected around the primary tumour and single photon emission CT images are obtained to locate the SLN. The SLN is the “first node to drain the region of interest” with tumour spread to this SLN prior to spread to any other nodes of the basin – a concept well established in other solid organ cancers such as breast and melanoma. Handheld gamma probe is used to locate SLN during the surgery and typically one or two nodes are excised, if these prove to be negative the patient has been saved an unnecessary neck dissection. In the setting of a positive SLNB the patient proceeds to a neck dissection as a second surgical procedure. SLNB thus de-escalates treatment related morbidity while not compromising on oncological outcomes.en_AU
dc.language.isoenen_AU
dc.subjectsentinel lymph nodeen_AU
dc.subjectneck dissectionen_AU
dc.subjectoral canceren_AU
dc.subjectlymphoscintigraphyen_AU
dc.subjecttongue canceren_AU
dc.subjecthead and neck canceren_AU
dc.subjectradiationen_AU
dc.subjectoral surgeryen_AU
dc.titleEvaluation of sentinel node biopsy in accurately staging oral cavity squamous cell carcinomaen_AU
dc.typeThesis
dc.type.thesisDoctor of Philosophyen_AU
dc.rights.otherThe author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.en_AU
usyd.facultySeS faculties schools::Faculty of Medicine and Health::Westmead Clinical Schoolen_AU
usyd.degreeDoctor of Philosophy Ph.D.en_AU
usyd.awardinginstThe University of Sydneyen_AU
usyd.advisorVeness, Michael
usyd.include.pubYesen_AU


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