The effect of swirl and capsule rotation on the fluid mechanics of dry powder inhalers.
Access status:
Open Access
Type
ThesisThesis type
Doctor of PhilosophyAuthor/s
Azeem, AthiyaAbstract
This thesis presents findings from an extensive study into the dispersion mechanisms that drive the performance of Dry Powder Inhaler (DPI) devices for pulmonary drug delivery. The design of DPIs and the subsequent air flow achieved play a critical role in powder deagglomeration ...
See moreThis thesis presents findings from an extensive study into the dispersion mechanisms that drive the performance of Dry Powder Inhaler (DPI) devices for pulmonary drug delivery. The design of DPIs and the subsequent air flow achieved play a critical role in powder deagglomeration which is necessary for lung deposition. The powder dispersion platforms fabricated for this contribution aim to explore the dynamic powder behaviour of swirl-based designs and capsule-based devices. High-speed microscopic imaging was employed within these devices to analyse the interactions between the air, device geometry, and the powder particles. This included quantifying powder dispersion using particle size measurements, and analysis of particle motion via particle tracking velocimetry.
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See moreThis thesis presents findings from an extensive study into the dispersion mechanisms that drive the performance of Dry Powder Inhaler (DPI) devices for pulmonary drug delivery. The design of DPIs and the subsequent air flow achieved play a critical role in powder deagglomeration which is necessary for lung deposition. The powder dispersion platforms fabricated for this contribution aim to explore the dynamic powder behaviour of swirl-based designs and capsule-based devices. High-speed microscopic imaging was employed within these devices to analyse the interactions between the air, device geometry, and the powder particles. This included quantifying powder dispersion using particle size measurements, and analysis of particle motion via particle tracking velocimetry.
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Date
2025Rights statement
The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.Faculty/School
Faculty of Engineering, School of Aerospace Mechanical and Mechatronic EngineeringAwarding institution
The University of SydneyShare