Design Optimization of Perfluorinated Liquid-Infused Surfaces for Blood-Contacting Applications
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Open Access
Type
ArticleAbstract
Tethered-liquid perfluorocarbon (TLP) coatings show promise for bloodcontacting
medical device applications to reduce blood adhesion and delay
thrombosis. However, their fabrication and longevity under external fluid flow
is not well characterized. A vapor phase silanization ...
See moreTethered-liquid perfluorocarbon (TLP) coatings show promise for bloodcontacting medical device applications to reduce blood adhesion and delay thrombosis. However, their fabrication and longevity under external fluid flow is not well characterized. A vapor phase silanization reaction leading to the formation of tethered-perfluorocarbon (TP) layers containing large bumpy aggregates, 300 ± 200 nm thick, on top of an underlying 35 ± 15 nm thick uniform coating is reported. The vapor phase method compares favorably to the well-established liquid phase deposition to reproducibly create slippery coatings on silicon and polystyrene with very low water sliding angles (2° ± 1°), without the need to control humidity conditions. The TP layer retains perfluorinated lubricants up to 20 000 s–1, using a cone-and-plate rheometer, with the higher viscosity lubricant perfluoroperhydrophenanthrene being more resistant to depletion than perfluorodecalin. TLP infused with either of the lubricants effectively reduces adhesion of fibrin from human whole blood relative to TP and control hydrophilic and hydrophobic surfaces. The combination of highly fluorinated TP coatings grafted from the vapor phase to create nanoscale structured surfaces infused with higher viscosity lubricant may be the most suitable combination for clinical applications of liquid-infused surfaces to reduce thrombosis in blood-contacting medical devices under flow.
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See moreTethered-liquid perfluorocarbon (TLP) coatings show promise for bloodcontacting medical device applications to reduce blood adhesion and delay thrombosis. However, their fabrication and longevity under external fluid flow is not well characterized. A vapor phase silanization reaction leading to the formation of tethered-perfluorocarbon (TP) layers containing large bumpy aggregates, 300 ± 200 nm thick, on top of an underlying 35 ± 15 nm thick uniform coating is reported. The vapor phase method compares favorably to the well-established liquid phase deposition to reproducibly create slippery coatings on silicon and polystyrene with very low water sliding angles (2° ± 1°), without the need to control humidity conditions. The TP layer retains perfluorinated lubricants up to 20 000 s–1, using a cone-and-plate rheometer, with the higher viscosity lubricant perfluoroperhydrophenanthrene being more resistant to depletion than perfluorodecalin. TLP infused with either of the lubricants effectively reduces adhesion of fibrin from human whole blood relative to TP and control hydrophilic and hydrophobic surfaces. The combination of highly fluorinated TP coatings grafted from the vapor phase to create nanoscale structured surfaces infused with higher viscosity lubricant may be the most suitable combination for clinical applications of liquid-infused surfaces to reduce thrombosis in blood-contacting medical devices under flow.
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Date
2022Source title
Adv, Mater. InterfacesVolume
22Publisher
WileyFunding information
ARC FT180100214Rights statement
"This is the peer reviewed version of the following article: Hong, J. K., Mathur, K., Ruhoff, A. M., Akhavan, B., Waterhouse, A., Neto, C., Design Optimization of Perfluorinated Liquid-Infused Surfaces for Blood-Contacting Applications. Adv. Mater. Interfaces 2022, 9, 2102214 which has been published in final form at https://doi.org/10.1002/admi.202102214. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."Faculty/School
The University of Sydney Multidisciplinary Centres and Institutes , Charles Perkins CentreShare