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dc.contributor.authorLuo Qen_AU
dc.contributor.authorO'Connell DLen_AU
dc.contributor.authorKahn Cen_AU
dc.contributor.authorYu XQen_AU
dc.date.accessioned2023-03-28T03:25:55Z
dc.date.available2023-03-28T03:25:55Z
dc.date.issued2017
dc.date.issued2017en
dc.identifier.urihttps://hdl.handle.net/2123/30997
dc.identifier.urihttps://hdl.handle.net/2123/30997
dc.description.abstractNo previous Australian population-based studies have described or quantified the progression of colorectal cancer (CRC) to metastatic disease. We describe patterns of progression to metastatic disease for an Australian cohort diagnosed with localised or regional CRC.All localised and regional CRC cases in the New South Wales Cancer Registry diagnosed during 2000-2007 were followed to December 2011 for subsequent metastases (identified by subsequent disease episode notifications) or CRC death. Cox regression was used to identify factors associated with metastatic progression.After a median 5.3 years follow-up, 26.4% of the 12757 cases initially diagnosed with localised or regional colon cancer had developed metastatic disease, as had 29.5% of the 7154 rectal cancer cases. For both cancer sites, risk of metastatic progression was significantly higher for those initially diagnosed with regional disease (adjusted hazard ratio [aHR] 3.49 for colon, 2.66 for rectal cancer), and for older cases (e.g. aHR for >79years vs <60years: 1.38 for colon, 1.69 for rectal cancer). Risk of disease progression was significantly lower for females, and varied by histology type. For colon cancer, the risk of disease progression decreased over time. For rectal cancer, risk of metastatic progression was significantly higher for those living in more socioeconomically disadvantaged areas compared with those in the least disadvantaged area.An understanding of the variation in risk of metastatic progression is useful for planning health service requirements, and can help inform decisions about treatment and follow-up for colorectal cancer patients.en_AU
dc.publisherCancer Epidemiologyen_AU
dc.subject.otherCancer Type - Bowel & Colorectal Canceren_AU
dc.subject.otherCancer Control, Survivorship, and Outcomes Research - Surveillanceen_AU
dc.titleColorectal cancer metastatic disease progression in Australia: a population-based analysisen_AU
dc.typeArticleen_AU
dc.identifier.doi10.1016/j.canep.2017.05.012
dc.identifier.doi10.1016/j.canep.2017.05.012
dc.relation.otherXQY was supported by a NHMRC Fellowship (GNT550002)en_AU


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