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dc.contributor.authorBegg CBen_AU
dc.contributor.authorKlotz JBen_AU
dc.contributor.authorZanetti Ren_AU
dc.contributor.authorGallagher RPen_AU
dc.contributor.authorDwyer Ten_AU
dc.contributor.authorRebbeck TRen_AU
dc.contributor.authorBerwick Men_AU
dc.contributor.authorHummer Aen_AU
dc.contributor.authorMujumdar Uen_AU
dc.contributor.authorArmstrong BKen_AU
dc.contributor.authorKricker Aen_AU
dc.contributor.authorMarrett LDen_AU
dc.contributor.authorMillikan RCen_AU
dc.contributor.authorGruber SBen_AU
dc.contributor.authorAnton-Culver Hen_AU
dc.date.issued2004
dc.date.issued2004en
dc.identifier.urihttps://hdl.handle.net/2123/30731
dc.description.abstractOBJECTIVE: Melanoma has been shown in numerous studies to be associated with sun exposure, and with host phenotypic factors of genetic origin. In this study we use information from a large series of incident cases of melanoma from an international population-based study to examine the patterns of incidence of melanoma in the first-degree relatives of these cases. METHODS: A total of 2508 incident cases of melanoma provided information on basic demographic data and pigmentary characteristics, in addition to detailed information on family history of melanoma. These data were used to examine the incidence rates ratios of melanoma in the relatives of cases in relation to population rates, and also with respect to phenotypic characteristics of the probands that have been shown to be associated with melanoma: mole counts, hair color, eye color, and skin sensitivity to the sun. RESULTS: The incidence rates reflect the underlying patterns of incidence in the source populations, with generally higher rates in the Australian sample, low rates in Italy, and intermediate rates in the USA and Canada. Also, rates are higher in men than in women, except at very young ages. Phenotypic characteristics of the probands were only weakly associated with the observed rates in the relatives although there is a strong inverse association with age at diagnosis. Cumulative risk of melanoma rises to 6.9% (6.1%) at age 80 in male (female) first-degree relatives of cases, and to 10.8% (9.5%) in relatives of cases diagnosed before age 50. CONCLUSIONS: Relatives of cases diagnosed with melanoma are at considerable lifetime risk of the disease, especially if the case is diagnosed at a young ageen_AU
dc.publisherCancer Causes and Controlen_AU
dc.subjectAdulten_AU
dc.subjectEye Coloren_AU
dc.subjectFamilyen_AU
dc.subjectFamily Healthen_AU
dc.subjectFemaleen_AU
dc.subjectGenetic Predisposition to Diseaseen_AU
dc.subjectgeneticsen_AU
dc.subjectHair Coloren_AU
dc.subjecthistoryen_AU
dc.subjectHumansen_AU
dc.subjectIncidenceen_AU
dc.subjectAge Factorsen_AU
dc.subjectItalyen_AU
dc.subjectMaleen_AU
dc.subjectMelanomaen_AU
dc.subjectmethodsen_AU
dc.subjectMiddle Ageden_AU
dc.subjectNorth Americaen_AU
dc.subjectPhenotypeen_AU
dc.subjectResearch Support,Non-U.S.Gov'ten_AU
dc.subjectResearch Support,U.S.Gov't,P.H.S.en_AU
dc.subjectRisken_AU
dc.subjectAgeden_AU
dc.subjectSex Distributionen_AU
dc.subjectsun exposureen_AU
dc.subjectWomenen_AU
dc.subjectAustraliaen_AU
dc.subjectCanadaen_AU
dc.subjectcanceren_AU
dc.subjectCohort Studiesen_AU
dc.subjectdiagnosisen_AU
dc.subjectepidemiologyen_AU
dc.subject.otherCancer Control, Survivorship, and Outcomes Research - Resources and Infrastructureen_AU
dc.subject.otherCancer Type - Skin Canceren_AU
dc.titleFamilial aggregation of melanoma risks in a large population-based sample of melanoma casesen_AU
dc.typeArticleen_AU


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