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dc.contributor.authorShafer LAen_AU
dc.contributor.authorJeffrey Ien_AU
dc.contributor.authorElias Ben_AU
dc.contributor.authorShearer Ben_AU
dc.contributor.authorCanfell Ken_AU
dc.contributor.authorKliewer Een_AU
dc.date.accessioned2023-03-28T03:15:04Z
dc.date.available2023-03-28T03:15:04Z
dc.date.issued2013
dc.date.issued2013en
dc.identifier.urihttps://hdl.handle.net/2123/30554
dc.identifier.urihttps://hdl.handle.net/2123/30554
dc.description.abstractBACKGROUND: Gardasil, a human papillomavirus (HPV) vaccine, began among grade 6 girls in Manitoba, Canada in 2008. In Manitoba, there is evidence that First Nations, Metis, and Inuit women (FNMI) have higher HPV prevalence, lower invasive cervical cancer (ICC) screening, and higher ICC incidence than all other Manitoban (AOM) women. We developed a mathematical model to assess the plausible impact of unequal vaccination coverage among school girls on future cervical cancer incidence. METHODS: We fit model estimated HPV prevalence and ICC incidence to corresponding empirical estimates. We used the fitted model to evaluate the impact of varying levels of vaccination uptake by FNMI status on future ICC incidence, assuming cervical screening uptake among FNMI and AOM women remained unchanged. RESULTS: Depending on vaccination coverage, estimated ICC incidence by 2059 ranged from 15% to 68% lower than if there were no vaccination. The level of cross-ethnic sexual mixing influenced the impact that vaccination rates among FNMI has on ICC incidence among AOM, and vice versa. The same level of AOM vaccination could result in ICC incidence that differs by up to 10%, depending on the level of FNMI vaccination. Similarly, the same level of FNMI vaccination could result in ICC incidence that differs by almost 40%, depending on the level of AOM vaccination. CONCLUSIONS: If we are unable to equalize vaccination uptake among all school girls, policy makers should prepare for higher levels of cervical cancer than would occur under equal vaccination uptakeen_AU
dc.publisherVaccineen_AU
dc.subjectadministration & dosageen_AU
dc.subjectcomplicationsen_AU
dc.subjectepidemiologyen_AU
dc.subjectEthnic Groupsen_AU
dc.subjectethnologyen_AU
dc.subjectFemaleen_AU
dc.subjectHPVen_AU
dc.subjectHumansen_AU
dc.subjectimmunologyen_AU
dc.subjectIncidenceen_AU
dc.subjectManitobaen_AU
dc.subjectAdolescenten_AU
dc.subjectmethodsen_AU
dc.subjectMiddle Ageden_AU
dc.subjectModels,Theoreticalen_AU
dc.subjectOtheren_AU
dc.subjectPapillomavirus Infectionsen_AU
dc.subjectPapillomavirus Vaccinesen_AU
dc.subjectPatient Acceptance of Health Careen_AU
dc.subjectPrevalenceen_AU
dc.subjectprevention & controlen_AU
dc.subjectResearchen_AU
dc.subjectAdulten_AU
dc.subjectSchoolsen_AU
dc.subjectscreeningen_AU
dc.subjectstatistics & numerical dataen_AU
dc.subjecttransmissionen_AU
dc.subjectUterine Cervical Neoplasmsen_AU
dc.subjectutilizationen_AU
dc.subjectVaccinationen_AU
dc.subjectWomenen_AU
dc.subjectAgeden_AU
dc.subjectCanadaen_AU
dc.subjectcanceren_AU
dc.subjectcervicalen_AU
dc.subjectCervical Canceren_AU
dc.subjectChilden_AU
dc.subject.otherCancer Type - Cervical Canceren_AU
dc.subject.otherPrevention - Vaccinesen_AU
dc.subject.otherCancer Control, Survivorship, and Outcomes Research - Health Services, Economic and Health Policy Analysesen_AU
dc.titleQuantifying the impact of dissimilar HPV vaccination uptake among Manitoban school girls by ethnicity using a transmission dynamic modelen_AU
dc.typeArticleen_AU
dc.identifier.doi10.1016/j.vaccine.2013.07.073
dc.identifier.doi10.1016/j.vaccine.2013.07.073


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