Surgical management of diffuse malignant mesothelioma

Abstract

The focus of this MS. thesis is the surgical management of both malignant pleural and peritoneal mesothelioma. Section I of this dissertation is devoted to the management of malignant pleural mesothelioma. In Chapter 1, a systematic review on extrapleural pneumonectomy-based multi-modality treatment is presented. Chapter 2 is a critical analysis of prospectively collected data on surgical management of pleural mesothelioma. Chapter 3 focuses on extrapleural pneumonectomy and Chapter 4 examines the pattern of recurrence following extrapleural pneumonectomy. Section II of the dissertation is dedicated to the management of malignant peritoneal mesothelioma. As part of my research, I conducted a multicenter registry study on cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma. Chapter 5 reviews the current literature on the combined treatment approach for peritoneal mesothelioma. Chapter 6 analyzes the prognostic indicators and survival results of 405 patients with peritoneal mesothelioma from this multicenter registry. In the final chapter, a novel tumor—node-metastasis (TNM) staging system for peritoneal mesothelioma is proposed.